Olivier Brison

Institut Gustave Roussy — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index4.2kcitations92works0.02yr avg
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Research Topics

DNA Repair Mechanisms(24), Hematopoietic Stem Cell Transplantation(14), Genomics and Chromatin Dynamics(11), Epigenetics and DNA Methylation(11), Genetics and Neurodevelopmental Disorders(11)

Publications92 total

ATR and TopBP1 oppose to control dormant origin building, providing a first defence against replication stress
2024Open Access
The balance between ATR and DDK activities controls TopBP1-mediated locking of dormant origins at the pre-IC stage
2023· 6 citedOpen Access
Mistimed origin licensing and activation stabilize common fragile sites under tight DNA-replication checkpoint activation
Nature Structural & Molecular Biology·2023· 11 citedOpen Access
Unscheduled origin building in S-phase upon tight CDK1 inhibition suppresses CFS instability
2020· 3 citedOpen Access
Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide
Nature Communications·2019· 104 citedOpen Access
Transcription-mediated organization of the replication initiation program across large genes sets up common fragile sites genome-wide
2019Open Access
Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage
Cell Reports·2016· 80 citedOpen Access
Updating the mechanisms of common fragile site instability: how to reconcile the different views?
Cellular and Molecular Life Sciences·2014· 59 citedOpen Access
Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes
Cell Reports·2013· 182 citedOpen Access
Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity
PLoS Genetics·2013· 131 citedOpen Access
Characterization at nucleotide resolution of the homogeneously staining region sites of insertion in two cancer cell lines
Nucleic Acids Research·2013· 17 citedOpen Access
Replication Dynamics: Biases and Robustness of DNA Fiber Analysis
Journal of Molecular Biology·2013· 139 cited
Common fragile sites: mechanisms of instability revisited
Trends in Genetics·2011· 244 cited
Molecular profiling of common fragile sites in human fibroblasts
Nature Structural & Molecular Biology·2011· 119 cited
Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome
Nature Communications·2011· 78 citedOpen Access
Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site
Nature·2011· 414 cited
Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions
EMBO Reports·2010· 18 citedOpen Access
Supplementary Material for: Two populations of double minute chromosomes harbor distinct amplicons, the <i>MYC</i> locus at 8q24.2 and a 0.43-Mb region at 14q24.1, in the SW613-S human carcinoma cell line
Figshare·2009Open Access
Two populations of double minute chromosomes harbor distinct amplicons, the &lt;i&gt;MYC&lt;/i&gt; locus at 8q24.2 and a 0.43-Mb region at 14q24.1, in the SW613-S human carcinoma cell line
Cytogenetic and Genome Research·2009· 10 cited
Replication fork movement sets chromatin loop size and origin choice in mammalian cells
Nature·2008· 216 cited
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Frequent Co-authors

Michelle Debatisse(11), Christian Lavialle(10), Gèrard Socié(9), Stéphane Koundrioukoff(6), Éliane Gluckman(6), Nazanine Modjtahedi(6), Benoît Le Tallec(5), C. Kédinger(5), A Letessier(4), Gaël A. Millot(4), Bernard Dutrillaux(4), George R. Stark(4), Thierry Frébourg(4), Nicole Fossar(4), Thomas Lamonerie(4), Anne-Marie Lachagès(3), Hervé Técher(3), Therese Wilhelm(3), Sandra Carignon(3), E Gluckman(3)