David S. Weinstein

Vividion Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index2.8kcitations80works7.62yr avg
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Research Topics

Estrogen and related hormone effects(11), Cytokine Signaling Pathways and Interactions(11), Global trade and economics(6), Economic Growth and Productivity(6), Carcinogens and Genotoxicity Assessment(6)

Publications80 total

A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth
Cancer Discovery·2025Open Access
Abstract C081: Discovery and characterization of AKT1-E17K mutant-selective inhibitors for the treatment of AKT1-E17K mutant cancers
Molecular Cancer Therapeutics·2025
Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2
Science·2025· 1 citedOpen Access
Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers
Journal of Medicinal Chemistry·2025· 2 citedOpen Access
Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2
2024· 1 citedOpen Access
Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid-Reducing Agent
Journal of Medicinal Chemistry·2024· 6 cited
Suppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue
2024· 11 citedOpen Access
S3397 Acute Esophageal Necrosis From Ingestion of Household Cleaners: Showcase of Endoscopic Imaging From Severe Caustic Injury
The American Journal of Gastroenterology·2024
S3361 Heterotopic Pancreatic Tissue at the Gastroesophageal Junction Mimicking Barrett’s Esophagus
The American Journal of Gastroenterology·2024
S4933 Renal Cell Carcinoma: An Unusual Presentation with Melena
The American Journal of Gastroenterology·2024· 1 cited
S2686 Pancreatic Tail Plasmacytoma Mimicking Primary Pancreatic Malignancy
The American Journal of Gastroenterology·2024
Author Correction: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Nature·2024· 1 citedOpen Access
Abstract IA003: Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Molecular Cancer Therapeutics·2024
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
Nature·2024· 89 cited
Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase
Cancer Research·2024· 2 cited
S4065 Kaposi’s Sarcoma: An Unusual Presentation With an Acute Small Bowel Obstruction
The American Journal of Gastroenterology·2023
S3306 Endoscopic Ultrasound Gallbladder Drainage to Treat … Hypoxia?
The American Journal of Gastroenterology·2023
Structure–activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4′ and C6 variations
Bioorganic & Medicinal Chemistry Letters·2023· 1 citedOpen Access
Increasing rate of pathologic upgrading in low risk prostate cancer patients in the active surveillance era.
PubMed·2022· 5 cited
Acute gastric perforation after leaving against medical advice: A case presentation
Trauma Case Reports·2021· 4 citedOpen Access
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Frequent Co-authors

Adriana Zupa-Fernandez(7), Lihong Cheng(7), James R. Burke(7), Ryan Moslin(6), John S. Tokarski(6), Joann Strnad(6), David J. Shuster(6), Kim W. McIntyre(6), Charu Chaudhry(6), Celia D’Arienzo(6), Luisa Salter–Cid(6), John E. Somerville(6), Joel C. Barrish(6), Kathleen M. Gillooly(5), Jeffrey Tredup(5), Percy H. Carter(5), Mark Cunningham(5), Hua Gong(5), Sium Habte(5), Deborah A. Holloway(5)