Robert A. Holt

University of British Columbia — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

123h-index147.8kcitations452works5.52yr avg
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Research Topics

Cancer Genomics and Diagnostics(73), Cancer Immunotherapy and Biomarkers(48), Immune Cell Function and Interaction(45), Genomics and Phylogenetic Studies(41), CAR-T cell therapy research(32)

Publications342 total

A <i>De Novo</i> Algorithm for Allele Reconstruction from Oxford Nanopore Amplicon Reads, with Application to <i>CYP2D6</i>
2025Open Access
Why Canada’s next big infrastructure investment should be in biomanufacturing
2025
Applying principles of vaccine development to oncomicrobial vaccines
Blood Advances·2025Open Access
Self-multimerization of mRNA LNP-derived antigen improves antibody responses
2025Open Access
BCMA CAR-T Cells Capable of IL-6-Neutralization Bifunctionally Reduce Cytokine Release Syndrome and IL-6-driven Myeloma Growth in Preclinical Models
Clinical Lymphoma Myeloma & Leukemia·2025
Identification of Novel DNA Sequence Motifs that Modulate Transcription in T cells
2025Open Access
Comprehensive Functional Self-Antigen Screening to Assess Cross-Reactivity in a Promiscuous Engineered T-cell Receptor
2025· 1 citedOpen Access
Abstract 4738: Androgen regulation of HER3 in prostate cancer differs by duration of treatment
Cancer Research·2025
Development and first-in-human CAR T therapy against the pathognomonic MiT-fusion driven protein GPNMB
2025· 2 citedOpen Access
Correction: Titmuss et al. Immune Activation Following Irbesartan Treatment in a Colorectal Cancer Patient: A Case Study. Int. J. Mol. Sci. 2023, 24, 5869
International Journal of Molecular Sciences·2024Open Access
6807 Evaluation of Tobacco Exposure and Teprotumumab Efficacy: Pooled Results from Acute TED Clinical Trials
Journal of the Endocrine Society·2024Open Access
A synthetic cytotoxic T cell platform for rapidly prototyping TCR function
npj Precision Oncology·2024· 4 citedOpen Access
SA56 Disease Severity Is Associated With Poorer Quality of Life Outcomes and Higher Costs in Thyroid Eye Disease (TED): Evidence From Systematic Literature Reviews (SLRs)
Value in Health·2024
#1706739 Efficacy of Teprotumumab in Phenotype Type I vs Type II Thyroid Eye Disease
Endocrine Practice·2024Open Access
Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes
OncoImmunology·2024· 6 citedOpen Access
Direct in vivo CAR T cell engineering
Trends in Pharmacological Sciences·2024· 70 citedOpen Access
Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22
Molecular Therapy Oncology·2024· 10 citedOpen Access
A Synthetic Cytotoxic T cell Platform for Rapidly Prototyping TCR Function
Research Square (Research Square)·2023Open Access
A Synthetic Cytotoxic T cell Platform for Rapidly Prototyping TCR Function
2023Open Access
Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in natural <i>Drosophila</i> populations
2023Open Access
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Frequent Co-authors

Steven J.M. Jones(29), Marco A. Marra(21), Andrew D. Cherniack(17), Reanne Bowlby(16), Richard A. Moore(15), Jacqueline E. Schein(14), Katherine A. Hoadley(14), Adrian Ally(13), Miruna Balasundaram(13), Gad Getz(12), Noreen Dhalla(12), İnanç Birol(11), Rebecca Carlsen(11), Eric Chuah(11), Rameen Beroukhim(11), Juok Cho(11), Nils Gehlenborg(11), Stacey Gabriel(10), Scott Frazer(10), David I. Heiman(10)