Jacquelyn J. Bower

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index887citations42works2.32yr avg
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Research Topics

Virus-based gene therapy research(10), RNA Interference and Gene Delivery(6), DNA Repair Mechanisms(5), CRISPR and Genetic Engineering(5), Corneal Surgery and Treatments(5)

Publications42 total

Adeno-associated vector corneal gene therapy reverses corneal clouding in a feline model of mucopolysaccharidosis VI
UNC Libraries·2025Open Access
Adeno-associated vector corneal gene therapy reverses corneal clouding in a feline model of mucopolysaccharidosis VI
PLoS ONE·2025Open Access
Allele-specific depletion of GNAQQ209L via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQQ209L uveal melanoma cells
Molecular Therapy Oncology·2025· 1 citedOpen Access
AAV vector transduction restriction and attenuated toxicity in hESCs via a rationally designed inverted terminal repeat
Nucleic Acids Research·2025· 4 citedOpen Access
P1178 A multi-centred retrospective cohort study comparing JAK inhibitor therapies in moderate to severe ulcerative colitis
Journal of Crohn s and Colitis·2025· 1 citedOpen Access
A chimeric anti-vascularization immunomodulator prevents high-risk corneal transplantation rejection via ex vivo gene therapy
Molecular Therapy·2024· 8 citedOpen Access
AAV-mediated expression of HLA-G for the prevention of experimental ocular graft vs. host disease
Molecular Therapy — Methods & Clinical Development·2023· 2 citedOpen Access
Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy
PLoS ONE·2022· 19 citedOpen Access
AAV Vector Transduction Restriction and Attenuated Toxicity in hESCs via a Rationally Designed Inverted Terminal Repeat
2022· 1 citedOpen Access
Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models
Journal of Visualized Experiments·2022· 2 cited
Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models
Journal of Visualized Experiments·2022· 2 cited
Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy
Viruses·2021· 16 citedOpen Access
Prevention of experimental autoimmune uveitis by intravitreal AAV-EqIL-10
Investigative Ophthalmology & Visual Science·2021· 3 citedOpen Access
Intracorneal sequential dosing of AAV-ArsB clears corneal opacity associated with mucopolysaccharidosis VI in a feline model
Investigative Ophthalmology & Visual Science·2021· 2 citedOpen Access
Injection volume alters recombinant Adeno-associated Virus 8 ttansduction efficiency and biodistribution
Investigative Ophthalmology & Visual Science·2021Open Access
Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells
UNC Libraries·2020Open Access
Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis
UNC Libraries·2020Open Access
Topoisomerase IIα maintains genomic stability through decatenation G2 checkpoint signaling
UNC Libraries·2020Open Access
Revised genetic requirements for the decatenation G2 checkpoint: The role of ATM
UNC Libraries·2020Open Access
Ocular tolerability and immune response to corneal intrastromal adeno-associated (AAV) iduronidase (IDUA) gene therapy in New Zealand White rabbits
Investigative Ophthalmology & Visual Science·2020Open Access
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Frequent Co-authors

Matthew L. Hirsch(18), Liujiang Song(16), Brian C. Gilger(10), Jacklyn H. Salmon(8), Stephen S. Leonard(5), William K. Kaufmann(5), Darby Roberts(5), ‎Raluca Dumitru(4), B. Matthew Fagan(4), Larysa Pevny(4), Xianglin Shi(4), Marila Cordeiro‐Stone(4), Dennis A. Simpson(4), Xianglin Shi(4), Telmo Llanga(4), Tomoko Hasegawa(4), R. Jude Samulski(3), Elizabeth Crabtree(3), Evan S. Dellon(3), Temitope O. Keku(3)