Matthew L. Hirsch

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index3.1kcitations137works2.02yr avg
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Research Topics

Virus-based gene therapy research(64), RNA Interference and Gene Delivery(30), CRISPR and Genetic Engineering(25), Viral Infectious Diseases and Gene Expression in Insects(13), Retinal Development and Disorders(12)

Publications137 total

Adeno-associated vector corneal gene therapy reverses corneal clouding in a feline model of mucopolysaccharidosis VI
UNC Libraries·2025Open Access
Adeno-associated vector corneal gene therapy reverses corneal clouding in a feline model of mucopolysaccharidosis VI
PLoS ONE·2025Open Access
Ocular toxicity, distribution, and shedding of intravitreal AAV-eqIL-10 in Horses
UNC Libraries·2025Open Access
Allele-specific depletion of GNAQQ209L via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQQ209L uveal melanoma cells
Molecular Therapy Oncology·2025· 1 citedOpen Access
AAV vector transduction restriction and attenuated toxicity in hESCs via a rationally designed inverted terminal repeat
Nucleic Acids Research·2025· 4 citedOpen Access
Ocular toxicity, distribution, and shedding of intravitreal AAV-eqIL-10 in horses
Molecular Therapy — Methods & Clinical Development·2024· 1 citedOpen Access
A chimeric anti-vascularization immunomodulator prevents high-risk corneal transplantation rejection via ex vivo gene therapy
Molecular Therapy·2024· 8 citedOpen Access
AAV-mediated expression of HLA-G for the prevention of experimental ocular graft vs. host disease
Molecular Therapy — Methods & Clinical Development·2023· 2 citedOpen Access
The profile of extreme tension wave front in aluminum
Journal of Materials Science·2023Open Access
Inhibition of experimental autoimmune uveitis by intravitreal AAV-Equine-IL10 gene therapy
PLoS ONE·2022· 19 citedOpen Access
AAV Vector Transduction Restriction and Attenuated Toxicity in hESCs via a Rationally Designed Inverted Terminal Repeat
2022· 1 citedOpen Access
Therapeutic Applications of Adeno-Associated Virus (AAV) Gene Transfer of HLA-G in the Eye
International Journal of Molecular Sciences·2022· 21 citedOpen Access
Promyelocytic Leukemia Protein Is a Cell-Intrinsic Factor Inhibiting Parvovirus DNA Replication
UNC Libraries·2021Open Access
Harnessing the Natural Biology of Adeno-Associated Virus to Enhance the Efficacy of Cancer Gene Therapy
Viruses·2021· 16 citedOpen Access
Prevention of experimental autoimmune uveitis by intravitreal AAV-EqIL-10
Investigative Ophthalmology & Visual Science·2021· 3 citedOpen Access
Immunomodulatory gene therapy for treatment of ocular graft vs host disease
Investigative Ophthalmology & Visual Science·2021· 2 citedOpen Access
Intracorneal sequential dosing of AAV-ArsB clears corneal opacity associated with mucopolysaccharidosis VI in a feline model
Investigative Ophthalmology & Visual Science·2021· 2 citedOpen Access
Injection volume alters recombinant Adeno-associated Virus 8 ttansduction efficiency and biodistribution
Investigative Ophthalmology & Visual Science·2021Open Access
Viral Single-Strand DNA Induces p53-Dependent Apoptosis in Human Embryonic Stem Cells
UNC Libraries·2020Open Access
Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice
UNC Libraries·2020· 3 citedOpen Access
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Frequent Co-authors

R. Jude Samulski(23), Chengwen Li(11), Brian C. Gilger(9), Liujiang Song(9), Telmo Llanga(7), Laura Conatser(5), Aravind Asokan(5), Jacquelyn J. Bower(5), Matthew H. Porteus(4), Jacklyn H. Salmon(4), Junjiang Sun(3), James Kempf(3), Thomas Elliott(3), Mavis Agbandje‐McKenna(3), R. Jude Samulski(3), Isabelle Richard(3), Prabhakar Bastola(3), Brian L. Ellis(2), Paul E. Monahan(2), Tal Kafri(2)