Ángel L. Pey

Universidad de Granada — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index3.5kcitations127works3.12yr avg
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Research Topics

Metabolism and Genetic Disorders(32), Enzyme Structure and Function(28), Genomics, phytochemicals, and oxidative stress(18), Porphyrin Metabolism and Disorders(17), Protein Structure and Dynamics(15)

Publications126 total

Minimized sample consumption for time-resolved serial crystallography applied to the redox cycle of human NQO1
Communications Chemistry·2026Open Access
Phosphorylation of Ser81 in human AGT reversibly inactivate enzyme function and mimics catalytic defects of certain PH1-causing mutations
2025Open Access
Nanobodies as therapies for loss-of-function misfolding diseases
2025Open Access
Engineered Oxalate Decarboxylase Boosts Activity and Stability for Biological Applications
ACS Omega·2025· 5 citedOpen Access
Active site tyrosine residues in human NQO1 homodimer are critical for non-synchronous enzyme catalysis at the two active sites
2025Open Access
The lack of trade-off between conformational stability and binding affinity in a nanobody with therapeutic potential for a misfolding disease
International Journal of Biological Macromolecules·2024· 3 cited
Thermodynamic versus kinetic basis for the high conformational stability of nanobodies for therapeutic applications
FEBS Letters·2024· 8 citedOpen Access
The lack of trade-off between conformational stability and binding affinity in a nanobody with therapeutic potential for a misfolding disease
2024· 1 citedOpen Access
Phosphorylation of cytosolic <scp>hPGK1</scp> affects protein stability and ligand binding: implications for its subcellular targeting in cancer
FEBS Journal·2024Open Access
Thermodynamic versus kinetic basis for the high conformational stability of nanobodies for therapeutic applications
2024· 4 citedOpen Access
Engineered Oxalate decarboxylase boosts activity and stability for biological applications
2024Open Access
Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1
2024· 3 citedOpen Access
Structural dynamics and functional cooperativity of human <scp>NQO1</scp> by ambient temperature serial crystallography and simulations
Protein Science·2024· 14 citedOpen Access
Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants
FEBS Letters·2024· 5 citedOpen Access
Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations
2023Open Access
Structural dynamics at the active site of the cancer‐associated flavoenzyme NQO1 probed by chemical modification with PMSF
FEBS Letters·2023· 6 citedOpen Access
Phenotypic Modulation of Cancer-Associated Antioxidant NQO1 Activity by Post-Translational Modifications and the Natural Diversity of the Human Genome
Antioxidants·2023· 4 citedOpen Access
Molecular Mechanisms, Genotype–Phenotype Correlations and Patient-Specific Treatments in Inherited Metabolic Diseases
Journal of Personalized Medicine·2023Open Access
Modular droplet injector for sample conservation providing new structural insight for the conformational heterogeneity in the disease-associated NQO1 enzyme
Lab on a Chip·2023· 13 citedOpen Access
Phosphorylation of Thr9 Affects the Folding Landscape of the N-Terminal Segment of Human AGT Enhancing Protein Aggregation of Disease-Causing Mutants
Molecules·2022· 4 citedOpen Access
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Frequent Co-authors

Aurora Martı́nez(13), Eduardo Salido(13), David J. Timson(11), Noel Mesa‐Torres(10), Encarnación Medina‐Carmona(7), Tomáš Majtán(6), Jan P. Kraus(6), José M. Sánchez‐Ruiz(5), Ana Cristina Calvo(5), Magdalena Ugarte(4), Luis Alfonso Martínez‐Cruz(4), Rogelio Palomino‐Morales(4), Knut Teigen(4), Alejandra Gámez(3), Belén Pérez(3), Lourdes R. Desviat(3), Ming Ying(3), Clare F. Megarity(3), Armando Albert(3), José L. Neira(3)