Jerry R. Colca

Rubius Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index6.2kcitations155works0.12yr avg
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Research Topics

Metabolism, Diabetes, and Cancer(66), Pancreatic function and diabetes(50), Peroxisome Proliferator-Activated Receptors(32), Adipose Tissue and Metabolism(30), Liver Disease Diagnosis and Treatment(20)

Publications155 total

Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice
GeroScience·2025Open Access
1982-LB: MPC-Directed Insulin Sensitizer MSDC-0602K Combines with Tirzepatide to Maintain Muscle Mass/Function and Restructure Adipose Tissue
Diabetes·2025
WED-376 Fibroblast activity assessed by PRO-C3 is prognostic for fibrosis progression in MASH patients treated with insulin sensitizer MSDC-0602 K during a phase IIb clinical trial
Journal of Hepatology·2025
<scp>ECM</scp> Biomarkers <scp>PRO</scp>‐<scp>C3</scp> and <scp>PRO</scp>‐<scp>C6</scp> Reveal the Anti‐Fibrotic Effect of the Insulin Sensitizer <scp>MSDC</scp>‐0602 K During <scp>EMMINENCE</scp> Randomised Clinical Trial
Liver international communications.·2025Open Access
Metabolic dysfunction and insulin sensitizers in acute and chronic disease
Expert Opinion on Investigational Drugs·2025· 1 cited
1582-P: Fasting Insulin as an Independent Predictor of Metabolic Dysfunction–Associated Steatohepatitis (MASH) Severity
Diabetes·2024
LBP-010 Azemiglitazone in combination with GLP1 agonists increases benefit and could preserve lean body mass
Journal of Hepatology·2024
Hyperinsulinemia, an overlooked clue and potential way forward in metabolic dysfunction–associated steatotic liver disease
Hepatology·2023· 10 cited
Insulin sensitizers in 2023: lessons learned and new avenues for investigation
Expert Opinion on Investigational Drugs·2023· 12 cited
Serological biomarkers PRO-C3 and PRO-C6 reveal the anti-fibrotic and pro-metabolic effects of MSDC-0602 K, an insulin sensitizer, in non-alcoholic steatohepatitis patients during the EMMINENCE phase IIb study
Journal of Hepatology·2023
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19
Science Immunology·2023· 39 citedOpen Access
Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism
Molecular Metabolism·2023· 53 citedOpen Access
Review of: "[Commentary] COVID-19 and Alzheimer's disease, closely related?"
2023Open Access
A dual MTOR/NAD+ acting gerotherapy
2023· 2 citedOpen Access
Re-routing Metabolism by the Mitochondrial Pyruvate Carrier Inhibitor MSDC-0160 Attenuates Neurodegeneration in a Rat Model of Parkinson’s Disease
Molecular Neurobiology·2022· 18 citedOpen Access
Metabolic Mechanisms Connecting Alzheimer’s and Parkinson’s Diseases: Potential Avenues for Novel Therapeutic Approaches
Frontiers in Molecular Biosciences·2022· 13 citedOpen Access
Mitochondrial Pyruvate Carrier Inhibition Initiates Metabolic Crosstalk to Stimulate Branched Chain Amino Acid Catabolism
2022· 4 citedOpen Access
Re-routing metabolism by the mitochondrial pyruvate carrier inhibitor MSDC-0160 attenuates neurodegeneration in a rat model of Parkinson’s disease
2022· 4 citedOpen Access
The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease
Molecular Metabolism·2021· 33 citedOpen Access
213-LB: Mechanisms of Metabolic Cross Talk between Mitochondrial Pyruvate Carrier Inhibition and Branched-Chain Amino Acid Catabolism in Hepatocytes
Diabetes·2021
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Frequent Co-authors

Michael L. McDaniel(17), William Graham McDonald(14), Nirmala Kotagal(8), John Turk(8), Rolf F. Kletzien(7), Brian N. Finck(6), Bryan A. Wolf(5), Barbara J. Palazuk(4), Kyle S. McCommis(4), Paul E. Lacy(4), Christopher Edwards(3), Patrick A. Vigueira(3), Cecilia Hofmann(3), Jay M. McDonald(3), M Landt(3), P G Comens(3), Beth A. Davison(2), Stephen A. Harrison(2), Gad Cotter(2), Naim Alkhouri(2)