Morten Langgård

Lundbeck (Denmark) — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index572citations25works0.02yr avg
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Research Topics

Phosphodiesterase function and regulation(8), Cholinesterase and Neurodegenerative Diseases(5), Receptor Mechanisms and Signaling(4), Photochemistry and Electron Transfer Studies(3), Spectroscopy and Quantum Chemical Studies(3)

Publications25 total

The Molecular Mechanism of PDE1 Regulation
Cells·2025Open Access
Structure activity investigations of substituted quinazolines in the pursuit of a selective PDE1 PET ligand
SSRN Electronic Journal·2025Open Access
Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia
Neuropharmacology·2021· 6 cited
The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin
Bioorganic & Medicinal Chemistry Letters·2017· 13 citedOpen Access
Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility
Bioorganic & Medicinal Chemistry Letters·2015· 11 citedOpen Access
Synthesis and SAR study of novel tricyclic pyrazoles as potent phosphodiesterase 10A inhibitors
European Journal of Medicinal Chemistry·2014· 53 citedOpen Access
Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex
Acta Crystallographica Section D Biological Crystallography·2014· 34 citedOpen Access
The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin
Bioorganic & Medicinal Chemistry Letters·2013· 44 citedOpen Access
N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors
Bioorganic & Medicinal Chemistry·2013· 27 citedOpen Access
Selective Inhibitors of PDE2, PDE9, and PDE10
Annual reports in medicinal chemistry·2013· 7 cited
4-Phenyl imidazoles: A novel class of phosphodiesterase 10A (PDE10A) inhibitors as a potential new generation of antipsychotics
2012· 1 cited
Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 55 citedOpen Access
Discovery of Phosphoric Acid Mono-{2-[(<i>E</i>/<i>Z</i>)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A Phosphonooxymethylene Prodrug of a Potent and Selective hA<sub>2A</sub>Receptor Antagonist
Journal of Medicinal Chemistry·2011· 36 citedOpen Access
Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors, part 2, Lead-optimisation.
2010
Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors
Bioorganic & Medicinal Chemistry·2010· 60 citedOpen Access
Combining Pharmacophore Fingerprints and PLS-Discriminant Analysis for Virtual Screening and SAR Elucidation
Journal of Chemical Information and Modeling·2008· 13 cited
A Fragment‐weighted Key‐based Similarity Measure for Use in Structural Clustering and Virtual Screening
QSAR & Combinatorial Science·2005· 8 cited
Raman Spectrum of the Phenyl Radical
The Journal of Physical Chemistry A·2001· 30 cited
Molecular and vibrational structure of 2,2′-dihydroxybenzophenone: infrared linear dichroism and quantum chemical calculations
Journal of Molecular Structure·1999· 22 cited
Molecular and vibrational structure of anthralin. Infrared linear dichroism spectroscopy and quantum chemical calculations
Journal of Molecular Structure·1999· 12 cited
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Frequent Co-authors

Jan Kehler(10), Claus T. Christoffersen(7), Jacob Nielsen(7), Christoffer Bundgaard(6), John Paul Kilburn(4), Tenna Juul Schrøder(4), Jens Spanget‐Larsen(4), Andreas Ritzén(3), Samsa Lindberg(3), Philip Maltas(3), Lena Tagmose(3), Lars Christian B. Rønn(3), Søren Thirup(3), Jacob Lauwring Andersen(3), Battistina Asproni(2), Gérard A. Pinna(2), Sebastian Leth Petersen(2), Søren Christensen(2), Laurent David(2), Jørgen Eskildsen(2)