D.A.R. Sanders

Arrowhead Pharmaceuticals (United States) — United States

Materials Science · Physical Sciences

32h-index8.4kcitations151works2.02yr avg
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Research Topics

Enzyme Structure and Function(66), Enzyme Production and Characterization(32), Carbohydrate Chemistry and Synthesis(26), Glycosylation and Glycoproteins Research(17), Amino Acid Enzymes and Metabolism(17)

Publications151 total

Characterization of Hepatitis B Virus Transcripts in Chronically HBV-Infected Chimpanzees and Patients Treated with ARC-520 siRNA Demonstrates Transcriptional Silencing of cccDNA
Viruses·2024· 2 citedOpen Access
Biophysical and biochemical characterization of the thioredoxin system from <i>Colwellia psychrerythraea</i>
Proteins Structure Function and Bioinformatics·2023· 1 citedOpen Access
Unraveling the unexpected aggregation behavior of Pyrazole-Based compounds Targeting Mycobacterium tuberculosis UDP-Galactopyranose mutase
Bioorganic & Medicinal Chemistry·2023Open Access
Unraveling the Unexpected Aggregation Behavior of Pyrazole-Based Compounds Targeting Mycobacterium Tuberculosis Udp-Galactopyranose Mutase
SSRN Electronic Journal·2023Open Access
Pyrazole and Triazole Derivatives as Mycobacterium tuberculosis UDP-Galactopyranose Inhibitors
Pharmaceuticals·2022· 11 citedOpen Access
Snapshots along the catalytic path of KabA, a PLP-dependent aminotransferase required for kanosamine biosynthesis in Bacillus cereus UW85
Journal of Structural Biology·2021· 2 cited
Crystal structure of KabA from Bacillus cereus UW85 with bound cofactor PMP
2020
Crystal structure of KabA from Bacillus cereus UW85 in complex with the plp external aldimine adduct with kanosamine-6-phosphate
2020
Crystal structure of KabA from Bacillus cereus UW85 in complex with the reduced internal aldimine and with bound Glutarate
2020
Crystal structure of KabA from Bacillus cereus UW85 in complex with the internal aldimine
2020
Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56N mutant with pyruvate bound in the active site
2020
Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56A mutant with pyruvate bound in the active site and L-lysine at the allosteric site
2020
Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88A mutant with pyruvate bound in the active site
2020
Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59K mutant with pyruvate bound in the active site and L-histidine bound at the allosteric site
2020
Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H56W mutant with pyruvate bound in the active site
2020
Dihydrodipicolinate synthase (DHDPS) from C.jejuni, H59K mutant with pyruvate bound in the active site
2020
B-factor analysis suggests that <scp>L</scp>-lysine and <i>R</i>,<i>R</i>-bis-lysine allosterically inhibit Cj.DHDPS enzyme by decreasing its protein dynamics
Acta Crystallographica Section A Foundations and Advances·2020Open Access
Kinetic and structural analysis of Escherichia coli phosphoenolpyruvate carboxykinase mutants
Biochimica et Biophysica Acta (BBA) - General Subjects·2020· 10 cited
Asparagine-84, a regulatory allosteric site residue, helps maintain the quaternary structure of Campylobacter jejuni dihydrodipicolinate synthase
Journal of Structural Biology·2019· 4 cited
Dihydrodipicolinate synthase (DHDPS) from C.jejuni, N84A mutant with pyruvate bound in the active site
2019
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Frequent Co-authors

K.E. Van Straaten(8), David R. J. Palmer(8), Susan G. W. Kaminskyj(6), Bernardine M. Pinto(5), Amira M. El-Ganiny(5), James H. Naismith(4), Yue Yuan(4), Daniel E. Koshland(3), Chris Whitfield(3), Sarathy Karunan Partha(3), John P. Oliver(3), Hongyan Zheng(3), Henry R. Bourne(2), Frank McCormick(2), Beth L. Gillece-Castro(2), Alma L. Burlingame(2), Michael McNeil(2), Kathryn A. Buss(2), Cheryl Ingram‐Smith(2), James G. Ferry(2)