Stuart A. Lipton

Scripps Research Institute — United States

Neuroscience · Life Sciences

142h-index80.8kcitations597works5.92yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(182), Alzheimer's disease research and treatments(74), Neuroinflammation and Neurodegeneration Mechanisms(64), HIV Research and Treatment(63), Nitric Oxide and Endothelin Effects(60)

Publications595 total

Proteome-wide profiling of S-nitrosylated proteins using the SNOTRAP probe and mass spectrometry-based detection
Nature Protocols·2025· 1 cited
The transcriptional and cellular landscape of cognitive resilience to Alzheimer’s disease
Frontiers in Molecular Neuroscience·2025· 1 citedOpen Access
Gasotransmitter signaling in the brain: New frontiers for therapeutics
Neurotherapeutics·2025· 1 citedOpen Access
Redox regulation of neuroinflammatory pathways contributes to damage in Alzheimer’s disease brain
2025Open Access
Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide
Nature Metabolism·2025· 11 citedOpen Access
Aberrant S-nitrosylation in the TCA cycle contributes to mitochondrial dysfunction, energy compromise, and synapse loss in neurodegenerative diseases
Neurotherapeutics·2025· 1 citedOpen Access
Redox modulation of the complement cascade contributes to synapse loss in Alzheimer's disease
Neurotherapeutics·2025· 3 citedOpen Access
Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer’s disease iPSC-derived cortical organoids
2025· 1 citedOpen Access
Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice
Journal of Clinical Investigation·2025· 4 citedOpen Access
diAcCA, a Pro-Drug for Carnosic Acid That Activates the Nrf2 Transcriptional Pathway, Shows Efficacy in the 5xFAD Transgenic Mouse Model of Alzheimer’s Disease
Antioxidants·2025· 6 citedOpen Access
S-Nitrosylation of CRTC1 in Alzheimer’s disease impairs CREB-dependent gene expression induced by neuronal activity
Proceedings of the National Academy of Sciences·2025· 8 citedOpen Access
Inflammaging, Neuroinflammation, and Synaptic Damage in Alzheimer's Disease
Elsevier eBooks·2025
Potential Disease-Modifying Pharmacological Therapy for Alzheimer’s Disease by Protecting Synapses Via Prevention of Hyperexcitability and E/I Imbalance
Translational Neuroscience·2025Open Access
Redox regulation, protein S-nitrosylation, and synapse loss in Alzheimer’s and related dementias
Neuron·2024· 26 citedOpen Access
A pro-drug derivative of carnosic acid activates the Nrf2 transcriptional pathway and shows efficacy in Alzheimer’s disease transgenic mice
Free Radical Biology and Medicine·2024
Detecting Boolean Asymmetric Relationships With a Loop Counting Technique and its Implications for Analyzing Heterogeneity Within Gene Expression Datasets
IEEE Transactions on Computational Biology and Bioinformatics·2024· 2 citedOpen Access
Using in vivo intact structure for system-wide quantitative analysis of changes in proteins
Nature Communications·2024· 6 citedOpen Access
Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids
Molecular Psychiatry·2024· 11 citedOpen Access
Single‐Cell Patch‐Clamp/Proteomics of Human Alzheimer's Disease iPSC‐Derived Excitatory Neurons Versus Isogenic Wild‐Type Controls Suggests Novel Causation and Therapeutic Targets
Advanced Science·2024· 18 citedOpen Access
Metabolic Bypass Rescues Aberrant S‐nitrosylation‐Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons
Advanced Science·2024· 18 citedOpen Access
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Frequent Co-authors

Maria Talantova(8), Nikolaus J. Sucher(6), Jiankun Cui(6), Lorenzo Galluzzi(5), John Abrams(5), Eric H. Baehrecke(5), Mikhail V. Blagosklonny(5), Wafik S. El‐Deiry(5), Michael O. Hengartner(5), Sharad Kumar(5), Walter Malorni(5), Tomohiro Nakamura(5), Zezong Gu(5), Dongxian Zhang(5), Shu‐ichi Okamoto(5), Ilio Vitale(4), Emad S. Alnemri(4), Simone Fulda(4), Douglas R. Green(4), Oliver Kepp(4)