Leslie Regad

Centre National de la Recherche Scientifique — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index807citations47works2.32yr avg
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Research Topics

Protein Structure and Dynamics(22), Computational Drug Discovery Methods(12), HIV/AIDS drug development and treatment(10), HIV Research and Treatment(9), Enzyme Structure and Function(8)

Publications47 total

Exploration of questionable backbone conformations in crystallographic structure models using a structural alphabet
Acta Crystallographica Section D Structural Biology·2025Open Access
Exploration of Multiconformers to Extract Information About Structural Deformation Undergone by a Protein Target: Illustration on the Bcl-xL Target
Molecules·2025· 2 citedOpen Access
Exploring therapeutic targets with the HMM-SA structural alphabet: Methods, tools, and application to HIV-2 protease
Biochimie·2025· 3 citedOpen Access
Blunted CD40-responsive enhancer activation in <i>CREBBP</i>-mutant lymphomas can be restored by enforced CD4 T-cell engagement
Blood·2025· 4 citedOpen Access
CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy
2023· 1 citedOpen Access
Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance
Communications Biology·2022· 15 citedOpen Access
Exploration of the Structural Asymmetry Induced by the Intrinsic Flexibility of HIV-2 Protease
Symmetry·2022· 2 citedOpen Access
Structural Impacts of Drug-Resistance Mutations Appearing in HIV-2 Protease
Molecules·2021· 4 citedOpen Access
Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease
BMC Molecular and Cell Biology·2020· 6 citedOpen Access
Exploration of the effects of sequence variations between HIV-1 and HIV-2 proteases on their three-dimensional structures
Journal of Biomolecular Structure and Dynamics·2019· 7 citedOpen Access
High Impact: The Role of Promiscuous Binding Sites in Polypharmacology
Molecules·2019· 13 citedOpen Access
HIV-1 protease, Gag and gp41 baseline substitutions associated with virological response to a PI-based regimen
Journal of Antimicrobial Chemotherapy·2019· 11 cited
Characterizing the structural variability of HIV-2 protease upon the binding of diverse ligands using a structural alphabet approach
Journal of Biomolecular Structure and Dynamics·2018· 10 citedOpen Access
A non-parametric method to compute protein-protein and protein-ligands interfaces. Application to HIV-2 protease-inhibitors complexes
2018· 3 citedOpen Access
Characterization of HIV-2 Protease Structure by Studying Its Asymmetry at the Different Levels of Protein Description
Symmetry·2018· 6 citedOpen Access
SAFlex: A structural alphabet extension to integrate protein structural flexibility and missing data information
PLoS ONE·2018· 2 citedOpen Access
Exploration of the effect of sequence variations located inside the binding pocket of HIV-1 and HIV-2 proteases
Scientific Reports·2018· 7 citedOpen Access
Analysis of the HIV-2 protease’s adaptation to various ligands: characterization of backbone asymmetry using a structural alphabet
Scientific Reports·2018· 11 citedOpen Access
Exploring the potential of a structural alphabet-based tool for mining multiple target conformations and target flexibility insight
PLoS ONE·2017· 10 citedOpen Access
Statistical Profiling of One Promiscuous Protein Binding Site: Illustrated by Urokinase Catalytic Domain
Molecular Informatics·2017· 4 citedOpen Access
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Frequent Co-authors

Anne‐Claude Camproux(34), Michel Petitjean(10), Delphine Flatters(10), Juliette Martin(8), Dhoha Triki(8), Benoît Visseaux(7), Alexandre Borrel(6), Grégory Nuel(6), Diane Descamps(6), Anne Badel(5), Hiba Abi Hussein(4), Colette Geneix(4), Natacha Cerisier(4), Pierre Laville(4), Fernando Rodrigues‐Lima(3), Sandrine Fartek(3), Henri Xhaard(2), Christelle Reynès(2), Bruno O. Villoutreix(2), Julien Maupetit(2)