Naoya Shindo

Kyushu University — Japan

Chemistry · Physical Sciences

16h-index1.3kcitations58works1.72yr avg
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Research Topics

Click Chemistry and Applications(17), Crystallization and Solubility Studies(13), X-ray Diffraction in Crystallography(13), Peptidase Inhibition and Analysis(10), Asymmetric Synthesis and Catalysis(8)

Publications58 total

β-Fluorovinylsulfonamide as a Highly Reactivity- and Structure-Tunable Electrophile for Covalent Targeting of Proteins
Journal of the American Chemical Society·2025· 1 cited
A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues
Journal of the American Chemical Society·2025· 5 cited
Backbone cleavage of peptides and proteins <i>via</i> cysteine <i>S</i>-fluoroacetylation
Chemical Communications·2025· 1 citedOpen Access
Inhibition of dynamin‐related protein 1‐filamin interaction improves systemic glucose metabolism
British Journal of Pharmacology·2024· 3 citedOpen Access
A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues
2024
Chemistry of Covalent Drugs: Chemical Reactions with Endogenous Proteins in Live Cells
Journal of Synthetic Organic Chemistry Japan·2024
Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines
Journal of Medicinal Chemistry·2023· 23 cited
CCDC 2276979: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice
Molecular Pharmacology·2023· 1 cited
Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease
Chemical Communications·2023
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease
Journal of Medicinal Chemistry·2022· 41 citedOpen Access
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease
2022Open Access
CCDC 2124400: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
CCDC 2124399: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide
Chemical Science·2022· 37 citedOpen Access
Selective Covalent Targeting of SARS-CoV-2 Main Protease by Enantiopure Chlorofluoroacetamide
2021Open Access
Selective Covalent Targeting of SARS-CoV-2 Main Protease by Enantiopure Chlorofluoroacetamide
2021Open Access
Recent progress in covalent warheads for in vivo targeting of endogenous proteins
Bioorganic & Medicinal Chemistry·2021· 57 cited
Fragment-Based Discovery of Irreversible Covalent Inhibitors of Cysteine Proteases Using Chlorofluoroacetamide Library
Chemical and Pharmaceutical Bulletin·2020· 14 citedOpen Access
Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins
Journal of the American Chemical Society·2020· 135 cited
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Frequent Co-authors

Akio Ojida(24), Kiyosei Takasu(20), Yoshiji Takemoto(13), Shigehiro Ohdo(8), Eiji Kawanishi(8), Hirokazu Fuchida(7), Hidetoshi Tokuyama(7), Satsuki Onitsuka(7), Hikaru Isogai(7), Rui Hamada(7), Tadanari Hiramoto(7), Naoya Matsunaga(6), Y. Takemoto(6), José M. M. Caaveiro(5), Satoru Koyanagi(5), Itaru Hamachi(5), Daiki Yamane(5), Keiko Kuwata(4), Keisuke Tokunaga(4), Yuya Hirose(4)