Klaus Brischwein

Merck (Germany) — Germany

Medicine · Health Sciences

17h-index1.9kcitations26works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(18), CAR-T cell therapy research(13), Glycosylation and Glycoproteins Research(6), Immunotherapy and Immune Responses(4), Immune Cell Function and Interaction(3)

Publications26 total

Antitumor Activity of an EpCAM/CD3-bispecific BiTE Antibody During Long-term Treatment of Mice in the Absence of T-cell Anergy and Sustained Cytokine Release
Journal of Immunotherapy·2009· 61 cited
Mode of cytotoxic action of T cell-engaging BiTE antibody MT110
Immunobiology·2009· 179 cited
Lysis of cancer cells by autologous T cells in breast cancer pleural effusates treated with anti-EpCAM BiTE antibody MT110
Breast Cancer Research and Treatment·2008· 21 citedOpen Access
Therapeutic window of an EpCAM/CD3-specific BiTE antibody in mice is determined by a subpopulation of EpCAM-expressing lymphocytes that is absent in humans
Cancer Immunology Immunotherapy·2008· 39 citedOpen Access
Ex vivo Therapie maligner Pleuraergüsse beim metastasierten Mammakarzinom mit dem bispezifischen anti EpCAM/CD3 Antikörper MT110
Langenbecks Archiv für Chirurgie. Supplement·2008
Therapeutic Window of MuS110, a Single-Chain Antibody Construct Bispecific for Murine EpCAM and Murine CD3
Cancer Research·2008· 89 cited
Strictly Target Cell-dependent Activation of T Cells by Bispecific Single-chain Antibody Constructs of the BiTE Class
Journal of Immunotherapy·2007· 188 cited
Therapeutic window of MuS110, a single-chain antibody construct bispecific for EpCAM (CD326) and CD3
Molecular Cancer Therapeutics·2007· 3 cited
Mode of action of MT110, a novel bispecific single-chain antibody construct of the BiTE class for treatment of adeno and squamous cell carcinoma expressing EpCAM (CD326)
2007· 1 cited
The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct
Cancer Immunology Immunotherapy·2007· 134 citedOpen Access
Activation of T Cells by Bispecific Single-Chain Construct MT103 (MEDI-538) Is Strictly Target Cell-Dependent.
Blood·2006
CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis
Molecular Immunology·2006· 108 cited
224 POSTER Characterization of a murine EpCAM/CD3-bispecific BiTE molecule as a surrogate for preclinical development of the human EpCAM/CD3-bispecific BiTE molecule MT110
European Journal of Cancer Supplements·2006
200 POSTER Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BITE class
European Journal of Cancer Supplements·2006
Exchanging human Fcγ1 with murine Fcγ2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model
Cancer Immunology Immunotherapy·2006· 14 citedOpen Access
Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3
Cancer Immunology Immunotherapy·2005· 54 citedOpen Access
MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors
Molecular Immunology·2005· 257 cited
Eradication of Tumors from a Human Colon Cancer Cell Line and from Ovarian Cancer Metastases in Immunodeficient Mice by a Single-Chain Ep-CAM-/CD3-Bispecific Antibody Construct
Cancer Research·2005· 127 cited
Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct
International Journal of Cancer·2005· 342 citedOpen Access
Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines
British Journal of Cancer·2005· 143 citedOpen Access
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Frequent Co-authors

Patrick A. Baeuerle(20), Peter Kufer(15), Bernd Schlereth(13), Grit Lorenczewski(8), Mathias Locher(7), Roman Kischel(6), Robert Hofmeister(5), Ralf Lutterbuese(5), Larissa Parr(5), Petra Lutterbuese(5), Maria Amann(4), Volker Gekeler(4), Peter Bader(4), Patrick Hoffmann(3), Sandrine Crommer(3), Nadja Prang(3), Petra Kleindienst(3), Iduna Fichtner(3), Stefan Pflanz(3), Jörg Volkland(3)