Maria Paola Costi

Biochemistry, Genetics and Molecular Biology · Life Sciences

36h-index4.6kcitations371works2.72yr avg
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Research Topics

Biochemical and Molecular Research(109), Colorectal Cancer Treatments and Studies(69), Trypanosoma species research and implications(47), Research on Leishmaniasis Studies(39), Enzyme Structure and Function(39)

Publications370 total

Targeting della risposta al danno del DNA nel carcinoma colorettale mediante la destabilizzazione del dimero della timidilato sintasi umana (hTS).
IRIS UNIMORE (University of Modena and Reggio Emilia)·2026
Mass Spectrometry Proteomics: A Key to Faster Drug Discovery
Journal of Medicinal Chemistry·2025· 2 citedOpen Access
Persistent myeloid cell reprogramming despite miltefosine treatment in leishmania-infected macaques
iScience·2025Open Access
Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach
Journal of Medicinal Chemistry·2025Open Access
Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics
European Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Abstract P04: TARGETING THYMIDYLATE SYNTHASE (HTS) SUPPRESSES COLORECTAL CANCER CELL GROWTH BY INDUCING DNA DAMAGE AND APOPTOSIS
Cancer Research·2025
Advancing Drug Risk Assessment with Tissue Models: Correlating QT Interval and APD90 Prolongation to Refine Proarrhythmic Risk Guidelines
2025
Design of 2-aminobenzothiazole derivatives targeting trypanosomatid PTR1 by a multidisciplinary fragment hybridization approach
2025Open Access
Design of 2-aminobenzothiazole derivatives targeting trypanosomatid PTR1 by a multidisciplinary fragment-based approach
2025Open Access
Identification of Pyrazolo-Piperidinone Derivatives Targeting Yap-Tead Interface 3 as Anticancer Agents Through Integrated Virtual Screening and Mass Spectrometry Proteomics
SSRN Electronic Journal·2025Open Access
Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation
Frontiers in Pharmacology·2024· 4 citedOpen Access
Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use
Open Research Europe·2024· 3 citedOpen Access
Drugs for Vector-Borne Protozoal Diseases in a One Health Scenario. A European Perspective
ACS Infectious Diseases·2024· 5 citedOpen Access
One Health and Vector-Borne Parasitic Diseases Virtual Special Issue
ACS Infectious Diseases·2024· 2 citedOpen Access
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells
Biology Direct·2024· 4 citedOpen Access
Optical tweezers to investigate at the single-molecule level the interaction of thymidylate synthase with its consensus mRNA
2024
Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use
Open Research Europe·2024· 6 citedOpen Access
Deciphering Host–Parasite Interplay in <i>Leishmania</i> Infection through a One Health View of Proteomics Studies on Drug Resistance
ACS Infectious Diseases·2024· 6 citedOpen Access
Intersite communication in dimeric enzymes highlighted by structural and thermodynamic analysis of didansyltyrosine binding to thymidylate synthases
Bioorganic Chemistry·2024· 3 citedOpen Access
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-<i>Trypanosoma brucei</i> Agents
ACS Infectious Diseases·2024· 3 citedOpen Access
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Frequent Co-authors

Stefania Ferrari(21), Donatella Tondi(15), Alberto Venturelli(14), Rosaria Luciani(11), Rebecca C. Wade(9), Brian K. Shoichet(8), Cecilia Pozzi(8), Stefano Mangani(8), Matteo Santucci(7), Anabela Cordeiro‐da‐Silva(7), Nuno Santarém(6), Carolina Borsoi Moraes(6), Sheraz Gul(6), Gaetano Marverti(5), F. Di Pisa(5), Chiara Borsari(5), Lúcio H. Freitas-Júnior(5), Maria Kuzikov(5), Bernhard Ellinger(5), Gesa Witt(5)