Kevin Greenslade

UCB Pharma (United Kingdom) — United Kingdom

Medicine · Health Sciences

11h-index727citations15works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(5), Wnt/β-catenin signaling in development and cancer(4), Bone health and osteoporosis research(3), Glycosylation and Glycoproteins Research(3), T-cell and B-cell Immunology(2)

Publications15 total

Recombinant sclerostin inhibits bone formation in vitro and in a mouse model of sclerosteosis
Journal of Orthopaedic Translation·2021· 20 citedOpen Access
Generation of two high affinity anti-mouse FcRn antibodies: Inhibition of IgG recycling in wild type mice and effect in a mouse model of immune thrombocytopenia
International Immunopharmacology·2018· 16 cited
Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration
mAbs·2018· 110 citedOpen Access
Blockade of the Neonatal Fc Receptor (FcRn) Represents an Effective Mechanism for the Removal of Pathogenic Autoantibodies in Primary Immune Thrombocytopenia
Blood·2017
Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions
Scientific Reports·2017· 47 citedOpen Access
Dampening of the bone formation response following repeat dosing with sclerostin antibody in mice is associated with up-regulation of Wnt antagonists
Bone·2017· 59 citedOpen Access
Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates
The Journal of Immunology·2017· 13 citedOpen Access
Up-regulation of Wnt antagonists contributes to the attenuated response of bone formation to repeat doses of sclerostin antibody in a mouse model
Bone Abstracts·2016
Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasone
Arthritis & Rheumatism·2011· 74 cited
Characterization of the Structural Features and Interactions of Sclerostin
Journal of Biological Chemistry·2009· 235 citedOpen Access
Alternative antibody Fab′ fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering
Protein Engineering Design and Selection·2007· 46 cited
Effects of hyaluronan on models of immediate and delayed hypersensitivity in the rat
International Journal of Immunopharmacology·1999· 4 cited
The Effects of Cyclooxygenase 2 Inhibitors on Cartilage Erosion and Bone Loss in a Model of Mycobacterium tuberculosis-Induced Monoarticular Arthritis in the Rat
Inflammation·1998· 38 cited
Effects of diacerhein on granuloma induced cartilage breakdown in the mouse
Osteoarthritis and Cartilage·1998· 65 citedOpen Access
Effets de la diacerhéine sur les concentrations de cytokines dans un modèle de dégradation du cartilage induite par granulome chez la souris.
La Revue du praticien·1997

Frequent Co-authors

Adrian Moore(6), Bryan Smith(4), Alison Eddleston(4), Martyn K. Robinson(3), Louis Christodoulou(3), Omar Qureshi(3), Shauna West(3), Frank R. Brennan(3), D. A. Willoughby(3), Gill Holdsworth(3), Alistair J. Henry(2), Andrea Kießling(2), Paul Atherfold(2), Daniel Lightwood(2), Kerry Tyson(2), Chandan Alam(2), Joby K. Jose(2), Zofia Stencel(2), Hishani Kirby(2), Hua Zhu Ke(2)