Frank Maley

New York State Department of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

59h-index12.4kcitations246works0.02yr avg
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Research Topics

Biochemical and Molecular Research(96), Enzyme Structure and Function(58), Glycosylation and Glycoproteins Research(36), Carbohydrate Chemistry and Synthesis(34), Colorectal Cancer Treatments and Studies(31)

Publications246 total

Functional identity of the active sites of crustacean and viral thymidylate synthases
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology·2009· 16 cited
Spectroscopic Analysis of Folate Binding to Thymidylate Synthase Active Site
Spectroscopy Letters·2009· 1 cited
Extracting dust from soil: A simple solution to a tricky task
The Science of The Total Environment·2008· 29 cited
Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: Calorimetric and crystallographic analysis of the K48Q mutant
The International Journal of Biochemistry & Cell Biology·2008· 10 citedOpen Access
Role of Y94 in Proton and Hydride Transfers Catalyzed by Thymidylate Synthase
Biochemistry·2007· 48 citedOpen Access
CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q COMPLEXED WITH 5NO2DUMP AND BW1843U89
2007
CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q COMPLEXED WITH DUMP
2007
Crystal structure of the thymidylate synthase k48q
2007
Significance of mutations on the structural perturbation of thymidylate synthase: Implications for their involvement in subunit exchange
Protein Science·2007· 4 citedOpen Access
Chloroviruses Encode a Bifunctional dCMP-dCTP Deaminase That Produces Two Key Intermediates in dTTP Formation
Journal of Virology·2007· 25 citedOpen Access
Structure of the Y94F mutant of<i>Escherichia coli</i>thymidylate synthase
Acta Crystallographica Section F Structural Biology and Crystallization Communications·2006· 9 citedOpen Access
Crystal structures of thymidylate synthase mutant R166Q: Structural basis for the nearly complete loss of catalytic activity
Journal of Biochemical and Molecular Toxicology·2006Open Access
Hydride Transfer versus Hydrogen Radical Transfer in Thymidylate Synthase
Journal of the American Chemical Society·2006· 36 cited
Crystal structures of thymidylate synthase mutant R166Q: Structural basis for the nearly complete loss of catalytic activity
Journal of Biochemical and Molecular Toxicology·2006· 10 cited
Binding and repression of translation of the cognate mRNA by <i>Trichinella spiralis</i> thymidylate synthase differ from the corresponding interactions of the human enzyme
Biochemical Journal·2005· 4 citedOpen Access
Three-Dimensional Structure of the R115E Mutant of T4-Bacteriophage 2‘-Deoxycytidylate Deaminase<sup>,</sup>
Biochemistry·2004· 25 cited
Protection of hematopoietic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene
Cancer Gene Therapy·2004· 17 cited
A Trojan Horse Approach for Silencing Thymidylate Synthase
Biochemistry·2004· 6 cited
Crystal structure of T4-bacteriophage deoxycytidylate deaminase, mutant R115E
2004
Human cytomegalovirus requires cellular deoxycytidylate deaminase for replication in quiescent cells
Journal of General Virology·2003· 10 cited
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Frequent Co-authors

Gladys F. Maley(23), Robert B. Trimble(13), Anthony L. Tarentino(11), Thomas H. Plummer(5), Frederick K. Chu(5), Edward Chu(5), Marlene Belfort(4), Donna Voeller(4), Carmen J. Allegra(4), W.R. Montfort(3), Joan Pedersen-Lane(3), Kathy M. Perry(2), Eric B. Fauman(2), Janet Finer-Moore(2), C. Aschele(2), Domizia Debernardis(2), G Tunesi(2), Alberto Sobrero(2), K. Biemann(2), James C. Byrd(2)