Ken Y. Chan

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index5.9kcitations50works50.32yr avg
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Research Topics

Virus-based gene therapy research(22), RNA Interference and Gene Delivery(16), CRISPR and Genetic Engineering(16), Single-cell and spatial transcriptomics(6), Viral Infectious Diseases and Gene Expression in Insects(5)

Publications50 total

Protein-guided RNA barcoding links transcriptomes to synaptic architecture
2026
Systematic multi-trait AAV capsid engineering for efficient gene delivery
Nature Communications·2024· 48 citedOpen Access
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery
Science·2024· 130 cited
Peripheral neuronal activation shapes the microbiome and alters gut physiology
Cell Reports·2024· 23 citedOpen Access
An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery
2023· 9 citedOpen Access
Publisher Correction: Spatial atlas of the mouse central nervous system at molecular resolution
Nature·2023· 3 citedOpen Access
A marmoset brain cell census reveals regional specialization of cellular identities
Science Advances·2023· 59 citedOpen Access
Systematic Multi-Trait AAV Capsid Engineering for Efficient Gene Delivery
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Systematic Multi-Trait AAV Capsid Engineering for Efficient Gene Delivery
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Spatial atlas of the mouse central nervous system at molecular resolution
Nature·2023· 200 citedOpen Access
Next-generation sequencing of AAV.CAP-Mac from Chuapoco et al. (2023) Nature Nanotechnology
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Next-generation sequencing of AAV.CAP-Mac from Chuapoco et al. (2023) Nature Nanotechnology
2023Open Access
Targeting AAV vectors to the central nervous system by engineering capsid–receptor interactions that enable crossing of the blood–brain barrier
PLoS Biology·2023· 66 citedOpen Access
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
Nature Nanotechnology·2023· 108 citedOpen Access
Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
2023· 3 citedOpen Access
Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
2023· 1 citedOpen Access
Intravenous functional gene transfer throughout the brain of non-human primates using AAV
2023· 3 citedOpen Access
Systematic multi-trait AAV capsid engineering for efficient gene delivery
2022· 11 citedOpen Access
Targeting AAV vectors to the CNS via <i>de novo</i> engineered capsid-receptor interactions
2022· 8 citedOpen Access
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Frequent Co-authors

Benjamin E. Deverman(37), Viviana Gradinaru(27), Isabelle G. Tobey(14), Yujia A. Chan(14), Qin Huang(12), Albert T. Chen(12), Min Jee Jang(11), Fatma-Elzahraa Eid(11), Qingxia Zheng(11), Binhui Zhao(10), Collin Challis(9), Nicholas C. Flytzanis(8), Thomas Beddow(8), Alon Greenbaum(7), Sripriya Ravindra Kumar(7), Rosemary C. Challis(7), Pradeep S. Rajendran(7), John D. Tompkins(7), Kalyanam Shivkumar(7), Simon Pacouret(7)