Thomas Beddow

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

5h-index317citations13works43.72yr avg
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Research Topics

RNA Interference and Gene Delivery(5), Virus-based gene therapy research(4), Cancer Immunotherapy and Biomarkers(3), CRISPR and Genetic Engineering(3), Complement system in diseases(3)

Publications13 total

Interrogating the tumor microenvironment (TME) in patients (pts) with head and neck mucosal squamous cell carcinoma (HNmSCC) treated with programmed death-1 (PD-1) inhibitors.
Journal of Clinical Oncology·2024
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery
Science·2024· 130 cited
Spatial mapping reveals unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers
2024· 1 citedOpen Access
An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery
2023· 9 citedOpen Access
Abstract PR12: High-dimensional spatial analysis of the tumor-microenvironment to determine metastatic disease progression and response and resistance to therapy in head and neck cancer
Clinical Cancer Research·2023
Targeting AAV vectors to the central nervous system by engineering capsid–receptor interactions that enable crossing of the blood–brain barrier
PLoS Biology·2023· 66 citedOpen Access
Elective neck dissection improves regional control in early oral squamous cell carcinoma
Australian Journal of Otolaryngology·2023· 1 citedOpen Access
Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
2023· 3 citedOpen Access
Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions
2023· 1 citedOpen Access
Targeting AAV vectors to the CNS via <i>de novo</i> engineered capsid-receptor interactions
2022· 8 citedOpen Access
A high-efficiency AAV for endothelial cell transduction throughout the central nervous system
Nature Cardiovascular Research·2022· 96 citedOpen Access
Assessment of an evidence-based laryngeal cancer fact sheet: A mixed methods study
Health Informatics Journal·2021· 2 citedOpen Access

Frequent Co-authors

Ken Y. Chan(8), Isabelle G. Tobey(8), Albert T. Chen(8), Yujia A. Chan(8), Benjamin E. Deverman(8), Andrew J. Barry(7), Fatma-Elzahraa Eid(7), Qin Huang(7), Qingxia Zheng(7), Hikari Sorensen(5), Binhui Zhao(5), Jonathan R. Clark(5), Cynthia Moncada-Reid(4), Christopher J. Walkey(4), M. Cecilia Ljungberg(4), William R. Lagor(4), Jason D. Heaney(4), Carsten E. Palme(4), Tsu‐Hui Low(4), Jason Wu(3)