George Chang

United States Food and Drug Administration — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

24h-index7.2kcitations75works2.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(23), Computational Drug Discovery Methods(21), Drug Transport and Resistance Mechanisms(14), Lipoproteins and Cardiovascular Health(10), High-Temperature Coating Behaviors(7)

Publications75 total

US Food and Drug Administration Approval Summary: Ribociclib With an Aromatase Inhibitor in the Adjuvant Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Stage II and III High-Risk Early Breast Cancer Treatment Setting
Journal of Clinical Oncology·2025· 1 cited
Prediction of human clearance using human liver microsomes and hepatocytes with 455 drugs
Drug Metabolism and Pharmacokinetics·2024
Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery
The AAPS Journal·2024· 1 cited
Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes
The AAPS Journal·2024· 6 cited
Comparison of Tumor Binding Across Tumor Types and Cell Lines to Support Free Drug Considerations for Oncology Drug Discovery
Journal of Pharmaceutical Sciences·2023· 2 cited
The Comparison of Machine Learning and Mechanistic In Vitro–In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance
Molecular Pharmaceutics·2023· 21 cited
Pleural Metastases of HER2-negative Salivary Duct Carcinoma
2023
In Vitro-In Vivo Extrapolation and Scaling Factors for Clearance of Human and Preclinical Species with Liver Microsomes and Hepatocytes
The AAPS Journal·2023· 38 cited
Identification of Organic Anion Transporter 2 Inhibitors: Screening, Structure-Based Analysis, and Clinical Drug Interaction Risk Assessment
Journal of Medicinal Chemistry·2022· 4 cited
Rare case of multifocal extradural and intramedullary neurosarcoidosis without pulmonary involvement: a case report and literature review
Spinal Cord Series and Cases·2021· 2 citedOpen Access
Providing the ‘Best’ Lipophilicity Assessment in a Drug Discovery Environment
2021· 2 citedOpen Access
Providing the ‘Best’ Lipophilicity Assessment in a Drug Discovery Environment
2021· 2 citedOpen Access
Evaluation of Prediction Accuracy for Volume of Distribution in Rat and Human Using In Vitro, In Vivo, PBPK and QSAR Methods
Journal of Pharmaceutical Sciences·2020· 34 cited
Microstructure evolutions upon Ni(Pt) silicidation and the different responses to the metal etch
Microelectronics Reliability·2020· 3 cited
Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes
European Journal of Pharmaceutical Sciences·2020· 36 cited
P142 - Evaluation of fraction unbound across five species and seven tissues and the impact of low temperature
Drug Metabolism and Pharmacokinetics·2020
Evaluation of Fraction Unbound Across 7 Tissues of 5 Species
Journal of Pharmaceutical Sciences·2019· 33 cited
How Often Should Patients with Lung Cancer Have Imaging Tests after Surgery?
2019Open Access
Structural attributes influencing unbound tissue distribution
European Journal of Medicinal Chemistry·2019· 34 cited
Correction to “Prediction of Fraction Unbound in Microsomal and Hepatocyte Incubations: A Comparison of Methods across Industry Datasets”
Molecular Pharmaceutics·2019· 1 citedOpen Access
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Frequent Co-authors

Christopher Keefer(13), Li Di(10), David A. Tess(7), Manthena V. S. Varma(5), W. Phucharoen(5), Robert A. Miller(5), Matthew D. Troutman(4), Dennis O. Scott(4), Keith Riccardi(4), Sangwoo Ryu(4), Anthony Carlo(4), Nathaniel A. Woody(4), Wayne C. Guida(3), W. Clark Still(3), R. Scott Obach(3), Stefanus J. Steyn(3), John P. Umland(3), Ye Che(3), Bruce A. Lefker(3), Jian Lin(3)