Christopher J. Wrighton

Joanneum Research — Austria

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.3kcitations44works0.02yr avg
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Research Topics

Virus-based gene therapy research(9), Xenotransplantation and immune response(9), Immune Response and Inflammation(6), Organ Transplantation Techniques and Outcomes(6), Cancer Research and Treatments(6)

Publications42 total

Prediction of Glucose Concentration in Post-Cardiothoracic Surgery Patients Using Continuous Glucose Monitoring
Diabetes Technology & Therapeutics·2011· 6 cited
Lipid‐Heparin Infusion Suppresses the IL‐10 Response to Trauma in Subcutaneous Adipose Tissue in Humans
Obesity·2010· 9 cited
Size-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymes
Toxicology and Applied Pharmacology·2009· 112 cited
Transcriptionally Targeted Nonviral Gene Transfer Using a β-Catenin/TCF-Dependent Promoter in a Series of Different Human Low Passage Colon Cancer Cells
Molecular Pharmaceutics·2006· 13 cited
Structural and Mechanistic Studies of Escherichia coli Nitroreductase with the Antibiotic Nitrofurazone
Journal of Biological Chemistry·2005· 213 citedOpen Access
Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70
Cancer Gene Therapy·2005· 12 cited
The structure of E. coli nitroreductase bound with the antibiotic nitrofurazone
2005
Optimization of a synthetic β-catenin-dependent promoter for tumor-specific cancer gene therapy
Molecular Therapy·2004· 32 citedOpen Access
An Oncolytic Adenovirus Vector Combining Enhanced Cell-to-Cell Spreading, Mediated by the ADP Cytolytic Protein, with Selective Replication in Cancer Cells with Deregulated <b> <i>Wnt</i> </b> Signaling
Cancer Research·2004· 52 citedOpen Access
Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.
University of Birmingham Research Portal (University of Birmingham)·2003· 78 cited
High-Level, β-Catenin/TCF-Dependent Transgene Expression in Secondary Colorectal Cancer Tissue
Molecular Therapy·2001· 25 citedOpen Access
Combined Adenovirus-Mediated Nitroreductase Gene Delivery and CB1954 Treatment: A Well-Tolerated Therapy for Established Solid Tumors
Molecular Therapy·2001· 53 citedOpen Access
Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression ofE. coli nitroreductase
International Journal of Cancer·2000· 76 citedOpen Access
Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954
Cancer Gene Therapy·2000· 64 cited
High level inhibition of HIV replication with combination RNA decoys expressed from an HIV-Tat inducible vector
Gene Therapy·1998· 25 cited
Adenovirus-Mediated Expression of a Dominant Negative Mutant of p65/RelA Inhibits Proinflammatory Gene Expression in Endothelial Cells Without Sensitizing to Apoptosis
The Journal of Immunology·1998· 83 citedOpen Access
EXPRESSION OF HUMAN THROMBOMODULIN COFACTOR ACTIVITY IN PORCINE ENDOTHELIAL CELLS1,2
Transplantation·1998· 55 cited
EXPRESSION OF HUMAN THROMBOMODULIN COFACTOR ACTIVITY IN PORCINE AORTIC ENDOTHELIAL CELLS
Transplantation·1998
A20 Inhibits NF-κB Activation in Endothelial Cells Without Sensitizing to Tumor Necrosis Factor–Mediated Apoptosis
Blood·1998· 159 citedOpen Access
A20 Inhibits NF-κB Activation in Endothelial Cells Without Sensitizing to Tumor Necrosis Factor–Mediated Apoptosis
Blood·1998· 9 citedOpen Access
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Frequent Co-authors

Fritz H. Bach(19), Simon C. Robson(11), Hans Winkler(8), Christiane Ferran(8), Wayne W. Hancock(8), Peter F. Searle(6), Daniel Candinas(6), Andrew Mountain(6), Kai S. Lipinski(5), Miguel P. Soares(4), Shane T. Grey(4), Lawrence S. Young(4), Andrew McShea(4), Hans Winkler(4), Karl M. Stuhlmeier(3), Paul R. Race(3), Andrew L. Lovering(3), Scott A. White(3), Eva I. Hyde(3), Meinrad Busslinger(3)