Michael Szelke

Ferring Pharmaceuticals (Switzerland) — Switzerland

Medicine · Health Sciences

22h-index1.7kcitations84works0.02yr avg
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Research Topics

Renin-Angiotensin System Studies(23), Chemical Synthesis and Analysis(18), Peptidase Inhibition and Analysis(13), Neuropeptides and Animal Physiology(11), Receptor Mechanisms and Signaling(11)

Publications84 total

Synthesis and biological activity of potent, low molecular weight renin inhibitors*
Journal of Peptide Research·1997· 11 cited
Potent in vivo inhibitors of rat renin: Analogues of human and rat angiotensinogen sequences containing different classes of pseudodipeptides at the scissile site*
Journal of Peptide Research·1997· 10 cited
ChemInform Abstract: Pyridone‐Based Peptidomimetic Inhibitors of Interleukin‐1β‐ converting Enzyme (ICE).
ChemInform·1997
New renin inhibitors containing novel analogues of statine
Journal of Peptide Research·1997· 13 cited
ChemInform Abstract: (3R)‐N‐(1‐(tert‐Butylcarbonylmethyl)‐2,3‐dihydro‐2‐oxo‐5‐(2‐pyridyl)‐ 1H‐1,4‐benzodiazepin‐3‐yl)‐N′‐(3(methylamino)phenyl)urea (YF476): A Potent and Orally Active Gastrin/CCK‐B Antagonist.
ChemInform·1997
PYRIDONE-BASED PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1β-CONVERTING ENZYME (ICE)
Bioorganic & Medicinal Chemistry Letters·1997· 30 cited
ChemInform Abstract: 4‐Cyanothiazolidides as Very Potent, Stable Inhibitors of Dipeptidyl Peptidase IV.
ChemInform·1997
(3<i>R</i>)-<i>N</i>-(1-(<i>tert</i>-Butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1<i>H</i>- 1,4-benzodiazepin-3-yl)-<i>N</i>‘-(3-(methylamino)phenyl)urea (YF476):  A Potent and Orally Active Gastrin/CCK-B Antagonist
Journal of Medicinal Chemistry·1997· 73 citedOpen Access
Identification and biological activity of novel peptidomimetic gastrin/CCK-B receptor agonists
Bioorganic & Medicinal Chemistry Letters·1996· 1 cited
4-cyanothiazolidides as very potent, stable inhibitors of dipeptidyl peptidase IV
Bioorganic & Medicinal Chemistry Letters·1996· 24 cited
ChemInform Abstract: 2‐Cyanopyrrolidides as Potent, Stable Inhibitors of Dipeptidyl Peptidase IV
ChemInform·1996
Mechanism of irritant-induced cough: Studies with a kinin antagonist and a kallikrein inhibitor
Lung·1996· 18 cited
Selective inhibitors of plasma kallikrein
Immunopharmacology·1996· 7 cited
2-cyanopyrrolidides as potent, stable inhibitors of dipeptidyl peptidase IV
Bioorganic & Medicinal Chemistry Letters·1996· 80 cited
Synthetic inhibitors of human tissue kallikrein
Immunopharmacology·1996· 19 cited
ChemInform Abstract: Synthesis and Biological Activity of 1‐Alkylcarbonylmethyl Analogues of YM022
ChemInform·1996
Synthesis and biological activity of 1-alkylcarbonylmethyl analogues of YM022
Bioorganic & Medicinal Chemistry Letters·1996· 19 cited
Synthesis and biological activity of 5-heteroaryl benzodiazepines: analogues of YM022
Bioorganic & Medicinal Chemistry Letters·1996· 8 cited
Inhibitors of thrombin containing arginine ketone derivatives
1995· 2 cited
Thrombin Inhibitors Based on Ketone Derivatives of Arginine and Lysine
Journal of enzyme inhibition·1995· 13 cited
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Frequent Co-authors

B Leckie(15), Butrus Atrash(14), D. Michael Jones(10), A. Hallett(9), Dylan M. Jones(8), Anthony F. Lever(7), Doreen M. Ashworth(6), James J. Morton(6), Allan Hallett(6), J.B. Cooper(5), Hamish Ryder(5), S.R. Beattie(5), T.L. Blundell(4), Graeme Semple(4), JAVIER SUEIRAS‐DIAZ(4), Gordon D. McIntyre(4), M. Tree(4), Brian T. Donovan(4), F. E. Watson(3), Laurence H. Pearl(3)