Magdalena M. Scharf

Philipps University of Marburg — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index147citations22works4.12yr avg
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Research Topics

Receptor Mechanisms and Signaling(10), Neuropeptides and Animal Physiology(5), Neuroscience and Neuropharmacology Research(3), Protein Structure and Dynamics(2), Protein Kinase Regulation and GTPase Signaling(2)

Publications22 total

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7
Nature Communications·2025· 1 citedOpen Access
SAG1.3-derived Frizzled-targeting small-molecule compounds
Journal of Biological Chemistry·2025· 1 citedOpen Access
In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulators
2025Open Access
Water molecules in the cannabinoid receptor 2 binding site crucially impact the discovery of novel ligands
European Journal of Medicinal Chemistry·2025Open Access
In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulators
2025Open Access
Water molecules in the cannabinoid receptor 2 binding site crucially impact the discovery of novel ligands
2025Open Access
GPCR FORUM— towards community-driven science powered by young investigators
The Project Repository Journal·2024Open Access
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology·2024· 15 citedOpen Access
Structural basis of frizzled 7 activation and allosteric regulation
Nature Communications·2024· 13 citedOpen Access
Structural Basis of Frizzled 7 Activation and Allosteric Regulation
2024Open Access
Frizzleds act as dynamic pharmacological entities
Trends in Pharmacological Sciences·2024· 13 citedOpen Access
SAG1.3-derived Frizzled-targeting negative allosteric modulators
2024Open Access
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology·2024· 14 citedOpen Access
Structural characterization of FZD7, the importance of water network and cholesterol for class F GPCRS
BIO Web of Conferences·2024Open Access
Editorial: New approaches for the discovery of GPCR ligands
Frontiers in Endocrinology·2023· 1 citedOpen Access
Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations
Nature Communications·2023· 23 citedOpen Access
EP4 Receptor Conformation Sensor Suited for Ligand Screening and Imaging of Extracellular Prostaglandins
Molecular Pharmacology·2023· 7 citedOpen Access
Viewpoint on the Second Transatlantic GPCR Symposium for Early Career Investigators
ACS Pharmacology & Translational Science·2022· 1 citedOpen Access
Analyzing Kinase Similarity in Small Molecule and Protein Structural Space to Explore the Limits of Multi-Target Screening
Molecules·2021· 16 citedOpen Access
A Focus on Unusual ECL2 Interactions Yields β<sub>2</sub>‐Adrenergic Receptor Antagonists with Unprecedented Scaffolds
ChemMedChem·2020· 16 citedOpen Access
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Frequent Co-authors

Gunnar Schulte(11), Lukas Grätz(10), Peter Kolb(9), Jan Voss(9), Julia Kinsolving(7), Paweł Kozielewicz(5), Julien Bous(5), Paula Morales(3), Antonella Di Pizio(3), Ogün Adebalı(3), David Carrasco‐Busturia(3), Björn Forsberg(3), Moritz Bünemann(2), Berkay Selçuk(2), Ainoleena Turku(2), Carl-Fredrik Bowin(2), Rawan Shekhani(2), Nuria Oliva‐Vilarnau(2), Tobias Koolmeister(2), Marlies Körber(2)