Peter Kolb

Philipps University of Marburg — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index3.9kcitations156works5.72yr avg
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Research Topics

Receptor Mechanisms and Signaling(63), Neuropeptides and Animal Physiology(30), Computational Drug Discovery Methods(29), Chemical Synthesis and Analysis(10), Neurotransmitter Receptor Influence on Behavior(9)

Publications155 total

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7
Nature Communications·2025· 1 citedOpen Access
Small-Molecule Activators of PRMT1: Discovery, Optimization, and Proapoptotic Effects in Pancreatic Cancer Cells
2025Open Access
Predicting compounds that interact with the 2 known agonist-induced conformations of the human β1-adrenoceptor
Molecular Pharmacology·2025· 1 citedOpen Access
p1/s1, a 3’-nucleotidase/nuclease, allows <i>Leishmania major</i> to circumvent host innate immune response mechanisms
2025Open Access
In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulators
2025Open Access
Water molecules in the cannabinoid receptor 2 binding site crucially impact the discovery of novel ligands
European Journal of Medicinal Chemistry·2025Open Access
Author Correction: In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor
Nature Communications·2025Open Access
In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor
Nature Communications·2025· 1 citedOpen Access
In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulators
2025Open Access
GPR3 ligands discovered through combined virtual and conformational biosensor-based screening
2025Open Access
Docking for Smoothened antagonist chemotypes not susceptible to a vismodegib-resistance mutation
European Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
Nature Communications·2025· 38 citedOpen Access
A Fluorescent Probe Enables the Discovery of Improved Antagonists Targeting the Intracellular Allosteric Site of the Chemokine Receptor CCR7
Journal of Medicinal Chemistry·2025· 6 citedOpen Access
Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling
Nature Communications·2025· 7 citedOpen Access
Water molecules in the cannabinoid receptor 2 binding site crucially impact the discovery of novel ligands
2025Open Access
Investigation of Muscarinic Acetylcholine Receptor M<sub>3</sub> Activation in Atomistic Detail: A Chemist's Viewpoint
ChemMedChem·2024· 1 citedOpen Access
A fluorescent probe enables the discovery of improved antagonists targeting the intracellular allosteric site of the chemokine receptor CCR7
2024· 2 citedOpen Access
Discovery and characterization of small-molecule TGR5 ligands with agonistic activity
European Journal of Medicinal Chemistry·2024· 8 citedOpen Access
G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits
Nature Communications·2024· 26 citedOpen Access
Community guidelines for GPCR ligand bias: IUPHAR review 32
UNC Libraries·2024Open Access
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Frequent Co-authors

Amedeo Caflisch(8), Jana Selent(7), Brian K. Shoichet(5), David E. Gloriam(5), Maria Martí-Solano(5), Moritz Bünemann(5), Florent Chevillard(5), Michel Bouvier(4), Danzhi Huang(4), Daniel M. Rosenbaum(3), John J. Irwin(3), Juan Carlos Mobarec(3), Evi Kostenis(3), Johanna K. S. Tiemann(3), David Aranda-García(3), Tomasz Maciej Stępniewski(3), Margherita Persechino(3), А.А. Федоров(3), Steven C. Almo(3), Frank M. Raushel(3)