David E. Gloriam

University of Copenhagen — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

48h-index14.0kcitations154works21.32yr avg
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Research Topics

Receptor Mechanisms and Signaling(121), Neuropeptides and Animal Physiology(57), Computational Drug Discovery Methods(26), Monoclonal and Polyclonal Antibodies Research(21), Chemical Synthesis and Analysis(17)

Publications154 total

Unlocking Scalable Ligand Residence Time Predictions with Koffee Unbinding Kinetics Simulations
2025
An online GPCR drug discovery resource
npj Drug Discovery.·2025· 1 citedOpen Access
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics
Neuron·2025· 21 cited
GPCR drug discovery: new agents, targets and indications
Nature Reviews Drug Discovery·2025· 123 cited
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
Nature Communications·2025· 38 citedOpen Access
A <i>bio. tools</i> collection of online resources for GPCR research
British Journal of Pharmacology·2025· 1 citedOpen Access
An online GPCR drug discovery resource
2025· 1 citedOpen Access
Structural basis of THC analog activity at the Cannabinoid 1 receptor
Nature Communications·2025· 10 citedOpen Access
Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery
Nature Reviews Drug Discovery·2025· 44 citedOpen Access
Generic residue numbering of the GAIN domain of adhesion GPCRs
Nature Communications·2025· 6 citedOpen Access
PGxDB: an interactive web-platform for pharmacogenomics research
Nucleic Acids Research·2024· 12 citedOpen Access
GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes
Nucleic Acids Research·2024· 55 citedOpen Access
Generic residue numbering of the GAIN domain of adhesion GPCRs
2024Open Access
Structural basis of Δ9-THC analog activity at the Cannabinoid 1 receptor
2024Open Access
Differential G protein activation by the long and short isoforms of the dopamine D<sub>2</sub> receptor
British Journal of Pharmacology·2024· 7 citedOpen Access
GproteinDb in 2024: new G protein-GPCR couplings, AlphaFold2-multimer models and interface interactions
Nucleic Acids Research·2023· 25 citedOpen Access
Ligand selectivity hotspots in serotonin GPCRs
Trends in Pharmacological Sciences·2023· 21 citedOpen Access
Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations
Nature Communications·2023· 23 citedOpen Access
Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT<sub>2A</sub> Receptor Agonists
ACS Chemical Neuroscience·2023· 21 citedOpen Access
A community Biased Signaling Atlas
Nature Chemical Biology·2023· 34 cited
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Frequent Co-authors

Alexander S. Hauser(12), Vignir Ísberg(9), Christian Munk(9), Robert Fredriksson(9), Helgi B. Schiöth(9), Kasper Harpsøe(8), Gáspár Pándy‐Szekeres(7), Albert J. Kooistra(7), Stefan Mordalski(5), M. Madan Babu(4), György M. Keserű(4), Malin C. Lagerström(4), Hans Bräuner‐Osborne(4), Andrzej J. Bojarski(3), Raymond C. Stevens(3), Thóra K. Bjarnadóttir(3), Patrik Rydberg(3), Lars Olsen(3), Pär J. Höglund(3), Michel Bouvier(3)