Patrik Rydberg

AstraZeneca (United Kingdom) — United Kingdom

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

27h-index2.3kcitations53works0.02yr avg

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Research Topics

Pharmacogenetics and Drug Metabolism(28), Computational Drug Discovery Methods(23), Metal-Catalyzed Oxygenation Mechanisms(15), Metabolomics and Mass Spectrometry Studies(8), Analytical Chemistry and Chromatography(7)

Publications53 total

XMetDB: an open access database for xenobiotic metabolism

14 cited

Journal of Cheminformatics·2016· 14 citedOpen Access

Quantum Mechanics/Molecular Mechanics Modeling of Drug Metabolism: Mexiletine N-Hydroxylation by Cytochrome P450 1A2

31 cited

Chemical Research in Toxicology·2016· 31 citedOpen Access

MOESM1 of XMetDB: an open access database for xenobiotic metabolism

Figshare·2016Open Access

Density Functional Theory Study on the Formation of Reactive Benzoquinone Imines by Hydrogen Abstraction

8 cited

Journal of Chemical Information and Modeling·2015· 8 cited

Mechanism of the N-Hydroxylation of Primary and Secondary Amines by Cytochrome P450

38 cited

Chemical Research in Toxicology·2015· 38 cited

Reactivity‐Based Approaches and Machine Learning Methods for Predicting the Sites of Cytochrome P450‐Mediated Metabolism

5 cited

Methods and principles in medicinal chemistry·2014· 5 cited

Trends in predicted chemoselectivity of cytochrome P450 oxidation: B3LYP barrier heights for epoxidation and hydroxylation reactions

30 cited

Journal of Molecular Graphics and Modelling·2014· 30 cited

Prediction of Cytochrome P450 Mediated Metabolism of Designer Drugs

6 cited

Current Topics in Medicinal Chemistry·2014· 6 cited

Use of density functional theory in drug metabolism studies

28 cited

Expert Opinion on Drug Metabolism & Toxicology·2013· 28 cited

FAst MEtabolizer (FAME): A Rapid and Accurate Predictor of Sites of Metabolism in Multiple Species by Endogenous Enzymes

52 cited

Journal of Chemical Information and Modeling·2013· 52 cited

Structure–Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators

2 cited

Journal of Chemical Information and Modeling·2013· 2 cited

WhichCyp: prediction of cytochromes P450 inhibition

65 cited

Bioinformatics·2013· 65 citedOpen Access

The Contribution of Atom Accessibility to Site of Metabolism Models for Cytochromes P450

45 cited

Molecular Pharmaceutics·2013· 45 cited

Enrichment of True Positives from Structural Alerts Through the Use of Novel Atomic Fragment Based Descriptors

3 cited

Molecular Informatics·2013· 3 cited

Atomic fragment-based descriptor test data

Figshare·2013Open Access

p450 metabolism examples

Figshare·2013Open Access

phase1metabolismfigure

Figshare·2013Open Access

WhichCyp SVM modelling data

Figshare·2013Open Access

RS-WebPredictor: a server for predicting CYP-mediated sites of metabolism on drug-like molecules

65 cited

Bioinformatics·2012· 65 citedOpen Access

Nitrogen Inversion Barriers Affect the N‐Oxidation of Tertiary Alkylamines by Cytochromes P450

4 cited

Angewandte Chemie·2012· 4 cited

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Frequent Co-authors

Lars Olsen(24), Ulf Ryde(14), David E. Gloriam(4), Jed Zaretzki(4), Curt M. Breneman(4), Per‐Ola Norrby(4), Thomas H. Rod(3), Charles Bergeron(3), Tao-wei Huang(2), Kristin P. Bennett(2), Michał Rostkowski(2), Ola Spjuth(2), Vasanthanathan Poongavanam(2), Chris Oostenbrink(2), Jimmy Heimdal(2), Richard Lonsdale(2), Jeremy N. Harvey(2), Adrian J. Mulholland(2), Flemming Steen Jørgensen(2), Martin S. Jørgensen(2)