Kasper Harpsøe

University of Copenhagen — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index3.8kcitations66works1.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(43), Nicotinic Acetylcholine Receptors Study(16), Neuroscience and Neuropharmacology Research(14), Neuropeptides and Animal Physiology(13), Computational Drug Discovery Methods(12)

Publications66 total

Exploring a Druggable Hydrophobic Tunnel in the 5-HT2A Receptor with Potent Phenethylamines
2025· 2 citedOpen Access
Synthesis, Pharmacological Characterization, and Binding Mode Analysis of 8-Hydroxy-Tetrahydroisoquinolines as 5-HT<sub>7</sub> Receptor Inverse Agonists
ACS Chemical Neuroscience·2025Open Access
Ligand selectivity hotspots in serotonin GPCRs
Trends in Pharmacological Sciences·2023· 21 citedOpen Access
Structure–Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT<sub>2A</sub> Receptor Agonists
ACS Chemical Neuroscience·2023· 21 citedOpen Access
A community Biased Signaling Atlas
Nature Chemical Biology·2023· 34 cited
Introducing Conformational Restraints on 25CN-NBOH: A Selective 5-HT<sub>2A</sub> Receptor Agonist
ACS Medicinal Chemistry Letters·2023Open Access
Comprehensive Peptide Cyclization Examination Yields Optimized APP Scaffolds with Improved Affinity toward Mint2
Journal of Medicinal Chemistry·2023· 12 cited
Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139
European Journal of Pharmacology·2023· 10 citedOpen Access
An Online Biased Signaling Atlas
2022· 1 citedOpen Access
Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HT<sub>2A</sub>Receptor Agonists
Journal of Medicinal Chemistry·2022· 29 citedOpen Access
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
Molecular Cell·2022· 145 citedOpen Access
Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139
Cell Research·2021· 32 citedOpen Access
A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro
Molecular Brain·2021· 28 citedOpen Access
Ligand-directed bias of G protein signaling at the dopamine D2 receptor
Cell chemical biology·2021· 40 citedOpen Access
Molecular Determinants Underlying Delta Selective Compound 2 Activity at δ-Containing GABAA Receptors
Molecular Pharmacology·2021· 4 citedOpen Access
Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors
Journal of Medicinal Chemistry·2021· 11 citedOpen Access
Structural insights into the lipid and ligand regulation of serotonin receptors
Nature·2021· 264 cited
Molecular determinants underlying DS2 activity at δ-containing GABA <sub>A</sub> receptors
2021· 1 citedOpen Access
Targeting the APP-Mint2 Protein–Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation
Journal of the American Chemical Society·2021· 19 citedOpen Access
Structural Determinants for the Mode of Action of the Imidazopyridine DS2 at d-containing g-Aminobutyric Acid Type A (GABAA) Receptors
2020· 1 citedOpen Access
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Frequent Co-authors

David E. Gloriam(37), Hans Bräuner‐Osborne(13), Thomas Balle(9), Anders A. Jensen(8), Alexander S. Hauser(7), Petrine Wellendorph(7), Bente Frølund(7), Vignir Ísberg(6), Christian Munk(6), Dan Peters(6), Kristian Strømgaard(6), Christina Birkedahl Falk‐Petersen(6), Ícaro A. Simon(5), Philip K. Ahring(5), Tommy Liljefors(5), Stefan Mordalski(4), Andrzej J. Bojarski(4), J.S. Kastrup(4), Rasmus P. Clausen(4), Michael Gajhede(4)