Wayne N. Frankel

Columbia University Irving Medical Center — United States

Neuroscience · Life Sciences

38h-index16.5kcitations97works2.22yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(41), Ion channel regulation and function(31), Genetics and Neurodevelopmental Disorders(15), Epilepsy research and treatment(10), Cellular transport and secretion(10)

Publications97 total

Rescue of Iqsec2 Knockout Mice with Human IQSEC2 Adeno-Associated Virus Mediated Gene Therapy
International Journal of Molecular Sciences·2025Open Access
A mouse model of <i>GRIN2D</i> developmental and epileptic encephalopathy recapitulates the human disease
Brain·2025· 1 citedOpen Access
Epilepsy Gene Discovery Needs Another Big Leap Forward
Epiliepsy currents/Epilepsy currents·2025Open Access
Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons
eLife·2024· 1 citedOpen Access
Author response: Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons
2024Open Access
Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on SST- and PV-expressing cortical GABAergic neurons
2024· 2 citedOpen Access
Author response: Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on SST- and PV-expressing cortical GABAergic neurons
2024Open Access
Effective knockdown-replace gene therapy in a novel mouse model of DNM1 developmental and epileptic encephalopathy
Molecular Therapy·2024· 14 citedOpen Access
Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on SST- and PV-expressing cortical GABAergic neurons
2024Open Access
Author response: Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on SST- and PV-expressing cortical GABAergic neurons
2024· 3 citedOpen Access
Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on somatostatin- and parvalbumin-expressing cortical GABAergic neurons
eLife·2024· 5 citedOpen Access
Heterozygous expression of a Kcnt1 gain-of-function variant has differential effects on SST- and PV-expressing cortical GABAergic neurons
2024Open Access
Aberrant Local Synchrony in Distinct Mouse Models of Epileptic Encephalopathy
2023Open Access
Heterozygous expression of a <i>Kcnt1</i> gain-of-function variant has differential effects on SST- and PV-expressing cortical GABAergic neurons
2023Open Access
Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency
PLoS Genetics·2023· 20 citedOpen Access
Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor
Frontiers in Cellular Neuroscience·2023· 14 citedOpen Access
Sensory regulation of absence seizures in a mouse model of Gnb1 encephalopathy
iScience·2022· 13 citedOpen Access
Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
Cell Reports·2022· 33 citedOpen Access
Single unit analysis and wide-field imaging reveal alterations in excitatory and inhibitory neurons in glioma
Brain·2022· 20 citedOpen Access
Sensory regulation of absence seizures in a mouse model of <i>Gnb1</i> encephalopathy
2022Open Access
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Frequent Co-authors

Verity A. Letts(12), Barbara Beyer(9), John M. Coffin(7), Sabrina Petri(5), David B. Goldstein(5), Cathleen Lutz(4), Connie L. Mahaffey(4), Michael J. Boland(4), Susan L. Ackerman(3), Kenro Kusumi(3), H. Steve White(3), Christopher D. Bostick(3), Mu Yang(3), Rebecca M. Boumil(3), Jia Jie Teoh(3), Slavé Petrovski(3), Jonathan P. Stoye(3), Bruce W. Birren(2), F S Bartlett(2), Colin Fletcher(2)