Eugene M. Fluder

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Computer Science · Physical Sciences

11h-index2.7kcitations21works0.02yr avg
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Research Topics

Computational Drug Discovery Methods(8), Chemical Synthesis and Analysis(5), Analytical Chemistry and Chromatography(4), Molecular spectroscopy and chirality(4), Click Chemistry and Applications(2)

Publications21 total

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Cell·2013· 1.7k citedOpen Access
Text Influenced Molecular Indexing (TIMI): A Literature Database Mining Approach that Handles Text and Chemistry.
ChemInform·2003
Text Influenced Molecular Indexing (TIMI):  A Literature Database Mining Approach that Handles Text and Chemistry
Journal of Chemical Information and Computer Sciences·2003· 16 cited
Principal component analysis combined with truncated-Newton minimization for dimensionality reduction of chemical databases
Mathematical Programming·2003· 10 cited
ChemInform Abstract: Protocols for Bridging the Peptide to Nonpeptide Gap in Topological Similarity Searches.
ChemInform·2001
Protocols for Bridging the Peptide to Nonpeptide Gap in Topological Similarity Searches
Journal of Chemical Information and Computer Sciences·2001· 136 cited
Mining the Chemical Quarry with Joint Chemical Probes:  An Application of Latent Semantic Structure Indexing (LaSSI) and TOPOSIM (Dice) to Chemical Database Mining
Journal of Medicinal Chemistry·2001· 14 cited
Latent Semantic Structure Indexing (LaSSI) for Defining Chemical Similarity
Journal of Medicinal Chemistry·2001· 30 cited
Chemical Similarity Searches Using Latent Semantic Structural Indexing (LaSSI) and Comparison to TOPOSIM
Journal of Medicinal Chemistry·2001· 20 cited
Chemical Similarity Using Physiochemical Property Descriptors
Journal of Chemical Information and Computer Sciences·1996· 265 cited
rRNA operon restriction derived taxa for<i>Streptomyces</i>(RiDiTS)
FEMS Microbiology Letters·1995· 6 cited
Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.
Proceedings of the National Academy of Sciences·1989· 232 cited
Modeling the Mechanism of Peptide Cleavage by Thermolysin
Annals of the New York Academy of Sciences·1985· 4 cited
Intermolecular Modeling Methods in Drug Design/Modeling the Mechanism of Peptide Cleavage by Thermolysin
Drug Information Journal·1984· 8 cited
ChemInform Abstract: TAUTOMERIZATION OF FORMAMIDE, 2‐PYRIDONE, AND 4‐PYRIDONE: AN AB INITIO STUDY
Chemischer Informationsdienst·1983
Tautomerization of formamide, 2-pyridone, and 4-pyridone: an ab initio study
Journal of the American Chemical Society·1982· 192 cited
ChemInform Abstract: EFFECT OF THE METHYL GROUP ROTATION ON THE RATE OF INTRAMOLECULAR PROTON EXCHANGE IN α‐METHYL‐β‐HYDROXYACROLEIN
Chemischer Informationsdienst·1980· 2 cited
Effect of the methyl group rotation on the rate of intramolecular proton exchange in .alpha.-methyl-.beta.-hydroxyacrolein
Journal of the American Chemical Society·1980· 22 cited
Proper functional representation of symmetric double minimum potentials
Chemical Physics Letters·1978· 8 cited
ChemInform Abstract: INTRAMOLECULAR HYDROGEN TUNNELING IN MALONALDEHYDE
Chemischer Informationsdienst·1978
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Frequent Co-authors

Suresh B. Singh(8), Robert P. Sheridan(6), Simon K. Kearsley(5), Jose R. De la Vega(5), Richard Hull(5), Joseph D. Andose(3), Peter Gund(3), H. Bernhard Schlegel(2), Robert B. Nachbar(2), Jan H. Busch(2), Graham Smith(2), David Hangauer(2), Bruce L. Bush(2), Eugene F. McIntyre(2), Bin Zhang(1), Chris Gaiteri(1), Liviu‐Gabriel Bodea(1), Zhi Wang(1), Joshua McElwee(1), Alexei A. Podtelezhnikov(1)