Luke W. Arbogast

National Institute of Standards and Technology — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index608citations25works0.32yr avg
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Research Topics

Protein purification and stability(15), Monoclonal and Polyclonal Antibodies Research(10), Protein Structure and Dynamics(8), Advanced NMR Techniques and Applications(7), Glycosylation and Glycoproteins Research(5)

Publications25 total

Multiplatform Benchtop NMR Interlaboratory Study of Model Liquid Dosage Forms of Pharmaceutical Products
Analytical Chemistry·2026Open Access
Characterization of Peptide–Preservative Interaction by AlphaFold, Molecular Dynamics Simulation, and NMR Spectroscopy
Molecular Pharmaceutics·2025
Characterization of Peptide-Preservative Interaction and Reversibility by NMR Spectroscopy
Molecular Pharmaceutics·2025· 1 cited
Solid-State NMR Characterization of Lyophilized Formulations of Monoclonal Antibody Therapeutics
Molecular Pharmaceutics·2023· 7 cited
Interlaboratory Studies Using the NISTmAb to Advance Biopharmaceutical Structural Analytics
Frontiers in Molecular Biosciences·2022· 10 citedOpen Access
Principal Component Analysis of 1D 1H Diffusion Edited NMR Spectra of Protein Therapeutics
Journal of Pharmaceutical Sciences·2021· 13 citedOpen Access
Principal component analysis for automated classification of 2D spectra and interferograms of protein therapeutics: influence of noise, reconstruction details, and data preparation
Journal of Biomolecular NMR·2020· 17 cited
Assessment of the Higher‐Order Structure of Formulated Monoclonal Antibody Therapeutics by 2D Methyl Correlated NMR and Principal Component Analysis
Current Protocols in Protein Science·2020· 14 citedOpen Access
Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional <sup>1</sup>H,<sup>13</sup>C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies
Analytical Chemistry·2020· 16 citedOpen Access
Best Practices in Utilization of 2D-NMR Spectral Data as the Input for Chemometric Analysis in Biopharmaceutical Applications
Journal of Chemical Information and Modeling·2020· 23 cited
Chemometric outlier classification of 2D-NMR spectra to enable higher order structure characterization of protein therapeutics
Chemometrics and Intelligent Laboratory Systems·2020· 10 citedOpen Access
Selective spin inversion in solution by magic field cross polarization
Journal of Magnetic Resonance·2019· 2 cited
Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics
mAbs·2018· 103 citedOpen Access
Selective suppression of excipient signals in 2D 1H–13C methyl spectra of biopharmaceutical products
Journal of Biomolecular NMR·2018· 22 cited
Heterologous recombinant expression of non-originator NISTmAb
mAbs·2018· 6 citedOpen Access
Multivariate Analysis of Two-Dimensional <sup>1</sup>H, <sup>13</sup>C Methyl NMR Spectra of Monoclonal Antibody Therapeutics To Facilitate Assessment of Higher Order Structure
Analytical Chemistry·2017· 74 citedOpen Access
Non-Uniform Sampling for All: More NMR Spectral Quality, Less Measurement Time.
PubMed·2017· 46 citedOpen Access
Characterization of Monoclonal Antibody Drug Products Using High Resolution NMR | NIST
2016
Application of Natural Isotopic Abundance 1H–13C- and 1H–15N-Correlated Two-Dimensional NMR for Evaluation of the Structure of Protein Therapeutics
Methods in enzymology on CD-ROM/Methods in enzymology·2015· 38 cited
2D 1HN, 15N Correlated NMR Methods at Natural Abundance for Obtaining Structural Maps and Statistical Comparability of Monoclonal Antibodies
Pharmaceutical Research·2015· 51 cited
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Frequent Co-authors

John P. Marino(18), Robert G. Brinson(14), Frank Delaglio(12), Joel R. Tolman(4), Mats Wikström(3), John E. Schiel(3), K. Wade Elliott(3), John P. Giddens(3), Houman Ghasriani(2), Yves Aubin(2), Jeffrey W. Hudgens(2), David A. Sheen(2), Katharina Yandrofski(2), Ananya Majumdar(2), Evan M. Hetrick(2), Ryan M. Evans(1), Anthony J. Kearsley(1), Geneviève Gingras(1), Gregory K. Pierens(1), Xinying Jia(1)