John P. Giddens

Revolution Medicines (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.9kcitations31works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Glycosylation and Glycoproteins Research(19), Monoclonal and Polyclonal Antibodies Research(17), Carbohydrate Chemistry and Synthesis(9), Galectins and Cancer Biology(7), HIV Research and Treatment(6)

Publications31 total

Contributors
Elsevier eBooks·2024Open Access
Advancing KRAS drug discovery: A deep dive into biochemical, biophysical, and cellular assays for the identification and optimization of KRAS inhibitors
Elsevier eBooks·2024
Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb
mAbs·2023· 9 citedOpen Access
Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs
Frontiers in Molecular Biosciences·2022· 4 citedOpen Access
Principal component analysis for automated classification of 2D spectra and interferograms of protein therapeutics: influence of noise, reconstruction details, and data preparation
Journal of Biomolecular NMR·2020· 17 cited
Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional <sup>1</sup>H,<sup>13</sup>C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies
Analytical Chemistry·2020· 16 citedOpen Access
PI-6 Construction and analysis of V3 glycopeptide antigens for HIV-1 vaccine design
JAIDS Journal of Acquired Immune Deficiency Syndromes·2019
Glycoengineering of Antibodies for Modulating Functions
Annual Review of Biochemistry·2019· 130 citedOpen Access
Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody
Proceedings of the National Academy of Sciences·2018· 94 citedOpen Access
Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 <i>N</i>-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition
Journal of Medicinal Chemistry·2018· 25 cited
Heterologous recombinant expression of non-originator NISTmAb
mAbs·2018· 6 citedOpen Access
Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine
ACS Central Science·2018· 37 citedOpen Access
Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies
International Journal of Molecular Sciences·2018· 19 citedOpen Access
Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses
Cell chemical biology·2017· 52 citedOpen Access
Systematic Synthesis and Binding Study of HIV V3 Glycopeptides Reveal the Fine Epitopes of Several Broadly Neutralizing Antibodies
ACS Chemical Biology·2017· 30 cited
Modulating IgG effector function by Fc glycan engineering
Proceedings of the National Academy of Sciences·2017· 319 citedOpen Access
Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies
Chemical Communications·2017· 19 cited
An Fc–Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor
ChemBioChem·2016· 3 cited
Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling
Journal of Biological Chemistry·2016· 116 citedOpen Access
Endo-F3 Glycosynthase Mutants Enable Chemoenzymatic Synthesis of Core-fucosylated Triantennary Complex Type Glycopeptides and Glycoproteins
Journal of Biological Chemistry·2016· 89 citedOpen Access
page 1 of 2Next →

Frequent Co-authors

Lai‐Xi Wang(23), Joseph V. Lomino(6), Qiang Yang(6), Jared Orwenyo(6), Hui Cai(5), Mohammed A. Amin(4), Roushu Zhang(4), Celia C. LaBranche(4), David C. Montefiori(4), John P. Marino(4), Tiezheng Li(3), Jeffrey V. Ravetch(3), Christian Toonstra(3), Luke W. Arbogast(3), Frank Delaglio(3), David J. DiLillo(2), Xin Tong(2), Meng‐Jung Chiang(2), Jay H. Kalin(2), Po‐Yuan Hsiao(2)