Michael Lutteropp

Amgen (Germany) — Germany

Medicine · Health Sciences

11h-index2.0kcitations28works2.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(7), T-cell and B-cell Immunology(6), Acute Myeloid Leukemia Research(6), Glycosylation and Glycoproteins Research(6), Hematopoietic Stem Cell Transplantation(5)

Publications28 total

An Innovative Approach to Optimize First‐In‐Human Minimal Anticipated Biological Effect Level Based Starting Dose in Oncology Trials for Bispecific T‐Cell Engagers: Experience from A Solid Tumor Bispecific T‐Cell Engager
Clinical Pharmacology & Therapeutics·2024· 2 cited
Data from Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule
2023Open Access
Data from Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule
2023Open Access
Supplementary Data from Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule
2023Open Access
Supplementary Data from Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule
2023Open Access
Preclinical Assessment of a MUC12-Targeted BiTE (Bispecific T-cell Engager) Molecule
Molecular Cancer Therapeutics·2021· 10 citedOpen Access
CD33/CD3-bispecific T-cell engaging (BiTE®) antibody construct targets monocytic AML myeloid-derived suppressor cells
Journal for ImmunoTherapy of Cancer·2018· 86 citedOpen Access
Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option
Oncogene·2018· 106 citedOpen Access
CD33/CD3-Bispecific T-Cell Engaging (BiTE®) Antibody Constructs Efficiently Target Monocytic CD14+ hla-DRlow IDO+ aml-MDSCs
Blood·2017· 2 cited
Embryonic thymopoiesis is initiated by an immune-restricted lympho-myeloid progenitor, independently of notch signaling
Experimental Hematology·2017
Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors
Nature Immunology·2016· 60 citedOpen Access
Embryonic thymopoiesis is initiated by an immune-restricted lympho-myeloid progenitor independently of notch signaling
Experimental Hematology·2016
Distinct myeloid progenitor–differentiation pathways identified through single-cell RNA sequencing
Nature Immunology·2016· 221 cited
Expression of Novel Immune Checkpoint Molecules PVR and PVRL2 Confers a Negative Prognosis to Patients with Acute Myeloid Leukemia and Their Blockade Augments T-Cell Mediated Lysis of AML Cells Alone or in Combination with the BiTE® Antibody Construct AMG 330
Blood·2015· 3 cited
Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
Nature·2013· 618 cited
Establishment of lympho-myeloid restricted progenitors prior to the emergence of definitive hematopoietic stem cells
Experimental Hematology·2013
FLT3-ITDs Instruct a Myeloid Differentiation and Transformation Bias in Lymphomyeloid Multipotent Progenitors
Cell Reports·2013· 42 citedOpen Access
Dicer is selectively important for the earliest stages of erythroid development
Blood·2012· 13 citedOpen Access
FLT3-ITDS INTRODUCE A MYELOID DIFFERENTIATION AND TRANSFORMATION BIAS IN LYMPHO-MYELOID MULTIPOTENT PROGENITORS
Haematologica·2012Open Access
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential
Nature Immunology·2012· 148 citedOpen Access
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Frequent Co-authors

Sten Eirik W. Jacobsen(17), Petter Woll(14), Adam J. Mead(12), Sidinh Luc(12), Claus Nerlov(11), Iain C. Macaulay(10), Deborah Atkinson(8), Natalija Buza-Vidas(8), Tiphaine Bouriez‐Jones(8), Tiago C. Luís(7), Helen Ferry(7), Hanane Boukarabila(6), Marella de Bruijn(6), Matthias G. Friedrich(6), Benno Rattel(6), Julie M. Bailis(6), Supat Thongjuea(5), Joana Carrelha(5), Takuo Mizukami(5), Roger Patient(5)