Richard Lindberg

Amgen (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index7.4kcitations51works0.02yr avg
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Research Topics

Fibroblast Growth Factor Research(11), Kruppel-like factors research(11), Epigenetics and DNA Methylation(9), Cytokine Signaling Pathways and Interactions(7), Protein Kinase Regulation and GTPase Signaling(6)

Publications51 total

Understanding the Physical Interactions in the FGF21/FGFR/β‐Klotho Complex: Structural Requirements and Implications in FGF21 Signaling
Chemical Biology & Drug Design·2012· 95 citedOpen Access
Pharmacological Targeting of Glucagon and Glucagon-Like Peptide 1 Receptors Has Different Effects on Energy State and Glucose Homeostasis in Diet-Induced Obese Mice
Journal of Pharmacology and Experimental Therapeutics·2011· 31 cited
The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21
Journal of Molecular Biology·2011· 17 cited
Mutational analysis of G-protein coupled receptor – FFA2
Biochemical and Biophysical Research Communications·2011· 21 cited
Allosteric rescuing of loss‐of‐function FFAR2 mutations
FEBS Letters·2010· 11 cited
Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)
Proceedings of the National Academy of Sciences·2010· 98 citedOpen Access
Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor
American Journal of Physiology-Endocrinology and Metabolism·2010· 55 cited
Generation of Novel Long-Acting Globular Adiponectin Molecules
Journal of Molecular Biology·2010· 16 cited
FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation
Journal of Biological Chemistry·2009· 177 citedOpen Access
Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in <i>ob</i>/<i>ob</i> mice
FEBS Letters·2009· 103 citedOpen Access
Long-Term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control, with Reversible α-Cell Hyperplasia and Hyperglucagonemia
Journal of Pharmacology and Experimental Therapeutics·2009· 102 cited
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects
American Journal of Physiology-Endocrinology and Metabolism·2009· 331 cited
Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in <i>ob/ob</i> mice
Proceedings of the National Academy of Sciences·2009· 87 citedOpen Access
Fully Human Monoclonal Antibodies Antagonizing the Glucagon Receptor Improve Glucose Homeostasis in Mice and Monkeys
Journal of Pharmacology and Experimental Therapeutics·2009· 129 cited
An Acyl-Ghrelin-Specific Neutralizing Antibody Inhibits the Acute Ghrelin-Mediated Orexigenic Effects in Mice
Molecular Pharmacology·2009· 56 cited
Mice Overexpressing Murine Oncostatin M (OSM) Exhibit Changes in Hematopoietic and Other Organs that Are Distinct from Those of Mice Overexpressing Human OSM or Bovine OSM
Veterinary Pathology·2008· 20 citedOpen Access
FGF21 N‐ and C‐termini play different roles in receptor interaction and activation
FEBS Letters·2008· 149 cited
Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Diabetes·2008· 1.1k citedOpen Access
C-terminal Tail of FGF19 Determines Its Specificity toward Klotho Co-receptors
Journal of Biological Chemistry·2008· 85 citedOpen Access
Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48<sup>−/−</sup>Lep<sup>ob/ob</sup>mice devoid of ApoE or Ldlr
American Journal of Physiology-Endocrinology and Metabolism·2007· 31 cited
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Frequent Co-authors

Murielle M. Véniant(13), Yang Li(12), Tony Hunter(11), Jennifer Weiszmann(10), Randy Hecht(7), Hongfei Ge(7), Xinle Wu(7), Bryan D. Lemon(7), Jing Xu(6), Jamila Gupte(6), Tony Hunter(5), David S. Middlemas(5), Nessa Hawkins(5), Wei Gu(5), H. Drucker(5), Glenn Sivits(4), Steven Vonderfecht(4), Yuesheng Li(4), Jennitte Stevens(4), Hai Yan(4)