David T. Barkan

Boston Biomedical (United States) — United States

Computer Science · Physical Sciences

13h-index2.8kcitations30works6.52yr avg
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Research Topics

Computational Drug Discovery Methods(5), SARS-CoV-2 and COVID-19 Research(4), vaccines and immunoinformatics approaches(4), Genomics and Phylogenetic Studies(3), Glycosylation and Glycoproteins Research(3)

Publications30 total

Preclinical characterization of EGT710, an oral non-peptidomimetic reversible covalent SARS-CoV-2 main protease inhibitor
npj Drug Discovery.·2025Open Access
Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness
Journal of Medicinal Chemistry·2024· 12 citedOpen Access
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
eLife·2022· 123 citedOpen Access
Author response: Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
2022· 2 citedOpen Access
Donor–Acceptor Pyridinium Salts for Photo-Induced Electron-Transfer-Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes Using Visible Light
Journal of the American Chemical Society·2022· 62 citedOpen Access
Defining the Substrate Envelope of SARS-CoV-2 Main Protease to Predict and Avoid Drug Resistance
2022· 12 citedOpen Access
Comprehensive fitness landscape of SARS-CoV-2 M <sup>pro</sup> reveals insights into viral resistance mechanisms
2022· 3 citedOpen Access
Morphological Characterization of Antibiotic Combinations
ACS Infectious Diseases·2021· 10 cited
Donor-Acceptor Pyridinium Salts for Photo-Induced Electron Transfer Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes using Visible Light
2021· 2 citedOpen Access
Donor-Acceptor Pyridinium Salts for Photo-Induced Electron Transfer Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes using Visible Light
2021· 3 citedOpen Access
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models
Science Translational Medicine·2021· 81 cited
Mapping the Heterogeneity of Histone Modifications on Hepatitis B Virus DNA Using Liver Needle Biopsies Obtained from Chronically Infected Patients
Journal of Virology·2019· 41 citedOpen Access
The Safety and Antiviral Activity of BZF961 with or without Ritonavir in Patients Infected with Hepatitis C Virus: A Randomized, Multicenter Trial
Clinical Therapeutics·2018
Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing <i>In Vitro</i> Susceptibility in Escherichia coli and Klebsiella pneumoniae
Antimicrobial Agents and Chemotherapy·2018· 38 citedOpen Access
Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23
BMC Bioinformatics·2016· 12 citedOpen Access
<i>In Vitro</i> Characterization of Human Cytomegalovirus-Targeting Therapeutic Monoclonal Antibodies LJP538 and LJP539
Antimicrobial Agents and Chemotherapy·2016· 29 citedOpen Access
Additional file 2: of Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23
Figshare·2016Open Access
Additional file 1: of Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23
Figshare·2016Open Access
Global Identification and Characterization of Both O-GlcNAcylation and Phosphorylation at the Murine Synapse
Molecular & Cellular Proteomics·2012· 415 citedOpen Access
Large scale analysis of synaptic phosphorylation and O‐GlcNAcylation reveals complex interplay between these post‐translational modifications
The FASEB Journal·2012
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Frequent Co-authors

Andrej Săli(11), Stephanie Moquin(7), Dustin Dovala(6), Julia M. Flynn(4), Neşe Kurt Yılmaz(4), Celia A. Schiffer(4), Daniel N. Bolon(4), Charles S. Craik(4), Ursula Pieper(3), Jonathan C. Trinidad(3), Alma L. Burlingame(3), Neha S. Samant(3), Gily Schneider-Nachum(3), Christopher R. Sarko(3), Thierry T. Diagana(3), Caleb Hoopes(3), Akash Mamon Sarkar(3), Nicholas Kuehl(3), Nicole Collins(3), Markus Schirle(3)