Sihem Boudina

Indiana University School of Medicine

Medicine · Health Sciences

41h-index10.4kcitations135works4.32yr avg
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Research Topics

Adipose Tissue and Metabolism(51), Mitochondrial Function and Pathology(35), Autophagy in Disease and Therapy(29), Cardiovascular Function and Risk Factors(25), Adipokines, Inflammation, and Metabolic Diseases(14)

Publications135 total

Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure
Nature Communications·2026Open Access
Diet-induced MASH liver fibrosis promoted by EphB2 can be targeted by small molecule tetramerization inhibitors
2025Open Access
N-acetylcarnosine attenuates age-associated declines in multi-organ systems to improve survival
Free Radical Biology and Medicine·2025
N-acetylcarnosine attenuates age-associated declines in multi-organ systems to improve survival
2025Open Access
Loss of hepatic autophagy induces α‐cell proliferation through impaired glutamine‐dependent gluconeogenesis
Physiological Reports·2025Open Access
Corrigendum to “Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice” [Journal of Molecular and Cellular Cardiology 113 (2017) 39–50].
Journal of Molecular and Cellular Cardiology·2025Open Access
Hypertension and obesity independently drive hypertrophy and alter mitochondrial metabolism in a mouse model of heart failure with preserved ejection fraction
Physiological Reports·2024· 1 citedOpen Access
Abstract We108: Adipocyte Enhancer Binding Protein 1 (AEBP1) Inhibition as a Potential Anti-Fibrotic Therapy in Heart Failure
Circulation Research·2024
Lipid-associated macrophages reshape BAT cell identity in obesity
Cell Reports·2024· 15 citedOpen Access
<i>EphB2</i> deficiency in hepatic stellate cells mitigates fibrogenesis in metabolic dysfunction-associated steatohepatitis by attenuating the TGFβ/SMAD signaling
Physiology·2024
Phenotyping adult mice with inducible depletion of sequestosome-1 (p62) in endothelial cells
Physiology·2024
Stem cell secretome treatment improves whole‐body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice
Aging Cell·2024· 13 citedOpen Access
Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2
Cardiovascular Research·2024· 9 citedOpen Access
Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function
The EMBO Journal·2024· 22 citedOpen Access
Mitofusin-2 Regulates Platelet Mitochondria and Function
Circulation Research·2023· 40 citedOpen Access
A Fluorogenic-Based Assay to Measure Chaperone-Mediated Autophagic Activity in Cells and Tissues
2023· 1 citedOpen Access
Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice
Circulation Heart Failure·2023· 14 citedOpen Access
Abstract P3192: Prdm16 Regulates Cardiac Metabolic Genes Through Perm1
Circulation Research·2023
<i>PRDM16</i> Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study
Circulation Genomic and Precision Medicine·2023· 13 citedOpen Access
BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis
Communications Biology·2023· 19 citedOpen Access
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Frequent Co-authors

E. Dale Abel(23), James E. Cox(7), Karla Maria Pereira Pires(7), Sandra Sena(6), Heather Theobald(6), J. David Symons(6), Vlad G. Zaha(5), Brian T. O’Neill(5), Robert C. Cooksey(5), Sheldon E. Litwin(5), Heiko Bugger(4), Olesya Ilkun(4), Benjamin Wayment(4), Joseph Tuinei(4), Yong Hwan Han(4), Adam R. Wende(3), Daniel P. Kelly(3), Jared Rutter(3), J. J. Wright(3), Jonathan Buchanan(3)