Toshiyuki Takai

Tohoku University — Japan

Medicine · Health Sciences

70h-index19.2kcitations276works1.32yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(81), Immune Cell Function and Interaction(75), T-cell and B-cell Immunology(69), Immune Response and Inflammation(41), Mast cells and histamine(28)

Publications276 total

Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils
Alzheimer s Research & Therapy·2025· 2 citedOpen Access
P2.06.33 Prognostic Significance and Therapeutic Potential of LILRB4 in Mdsc-Mediated Immunosuppression in NSCLC
Journal of Thoracic Oncology·2025
Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils
2024· 2 citedOpen Access
TLR7/8 stress response drives histiocytosis in SLC29A3 disorders
The Journal of Experimental Medicine·2023· 22 citedOpen Access
Prognostic impact of LILRB4 expression on tumor‐infiltrating cells in resected non‐small cell lung cancer
Thoracic Cancer·2023· 16 citedOpen Access
Fibronectin on target cells attenuates natural cytotoxicity of NK cells via myeloid immune checkpoint ILT3/LILRB4/gp49B
International Immunology·2023· 13 citedOpen Access
INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
iScience·2023· 34 citedOpen Access
LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells
The Tohoku Journal of Experimental Medicine·2023Open Access
Fibronectin-LILRB4/gp49B interaction negatively regulates osteoclastogenesis through inhibition of RANKL-induced TRAF6/TAK1/NF–kB/MAPK signaling
International Immunology·2022· 13 cited
1429 Immune receptor PIRB deletion impacts pancreatic cancer growth and anti-tumor immune response
Regular and Young Investigator Award Abstracts·2022Open Access
TLR7/8 stress response drives histiocytosis in SLC29A3 disorders
2022· 1 citedOpen Access
Myeloid immune checkpoint ILT3/LILRB4/gp49B can co-tether fibronectin with integrin on macrophages
International Immunology·2022· 14 citedOpen Access
Potential role of rhizosphere microbiome on root exudations and phosphorus uptake of rice under flooded soil culture
Research Square (Research Square)·2022Open Access
LILRB4 promotes tumor metastasis by regulating MDSCs and inhibiting miR-1 family miRNAs
OncoImmunology·2022· 51 citedOpen Access
In-Frame Mutation in Rice Teosinte Branched1 (Ostb1) Improves Productivity Under Phosphorus Deficiency
SSRN Electronic Journal·2022Open Access
Co-localization of Fibronectin Receptors LILRB4/gp49B and Integrin on Dendritic Cell Surface
The Tohoku Journal of Experimental Medicine·2022· 7 citedOpen Access
Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation
Respiratory Research·2021· 13 citedOpen Access
Upregulation of Leukocyte Immunoglobulin-Like Receptor B4 on Interstitial Macrophages in COPD; Their Possible Protective Role Against Emphysema Formation
2021Open Access
Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/<i>Yaa</i> mice
International Immunology·2021· 25 cited
Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/<i>Yaa</i> mice
The Journal of Immunology·2021
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Frequent Co-authors

Masao Ono(7), Shosaku Numa(6), Akira Nakamura(6), Masaharu Noda(5), Masanori Inui(5), Azusa Ujike(5), Jeffrey V. Ravetch(4), Takako Koga(4), Tatsuhiko Kodama(4), Marco Colonna(4), Shin Shimizu(3), Toshiaki Kayano(3), Hideo Takahashi(3), Tadaaki Hirose(3), Seiichi Inayama(3), Takashi Miyata(3), Masayoshi Mishina(3), Tomoyuki Takahashi(3), Ayako Suematsu(3), Hiroshi Takayanagi(3)