Jari Koıstınaho

University of Helsinki — Finland

Neuroscience · Life Sciences

74h-index25.0kcitations401works6.12yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(118), Alzheimer's disease research and treatments(79), Neuroscience and Neuropharmacology Research(43), Neuropeptides and Animal Physiology(34), Neurogenesis and neuroplasticity mechanisms(24)

Publications400 total

Human oligodendrocyte progenitor cells mediate synapse elimination through TAM receptor activation
Nature Communications·2025· 1 citedOpen Access
SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes differential accumulation of HIF1ɑ and phosphorylated tau
Universität Zürich, ZORA·2025Open Access
APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs
Fluids and Barriers of the CNS·2025Open Access
A schizophrenia-associated radial glia cell state perturbs early human brain development
2025Open Access
SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes differential accumulation of HIF1ɑ and phosphorylated tau
Molecular Therapy — Nucleic Acids·2025Open Access
W66. NEUROBIOLOGICAL CORRELATES OF MALE SEXUAL ORIENTATION
European Neuropsychopharmacology·2025Open Access
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Molecular Psychiatry·2025· 1 citedOpen Access
APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs
2025Open Access
Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain
Brain Behavior and Immunity·2025Open Access
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
Journal of Neuroinflammation·2025· 8 citedOpen Access
Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia
Environment International·2025· 5 citedOpen Access
Kynurenic Acid and Promotion of Activity-Dependent Synapse Elimination in Schizophrenia
American Journal of Psychiatry·2025· 5 cited
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
2025Open Access
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Journal of Neuroinflammation·2025· 9 citedOpen Access
miRNA profiling of hiPSC-derived neurons from monozygotic twins discordant for schizophrenia
Schizophrenia·2025Open Access
Additional file 1 of The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Figshare·2025Open Access
Additional file 3 of The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Figshare·2025Open Access
Additional file 4 of The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions
Figshare·2025Open Access
LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses
International Journal of Molecular Sciences·2024· 2 citedOpen Access
SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1ɑ and phosphorylated tau
2024· 1 citedOpen Access
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Frequent Co-authors

Tarja Malm(17), Gundars Goldsteins(14), Šárka Lehtonen(12), Katja M. Kanninen(10), Milla Koistinaho(9), Minna Oksanen(6), Sara Wojciechowski(6), Riitta Keinänen(5), Pak H. Chan(5), Anastasia Shakirzyanova(5), Seppo Ylä‐Herttuala(5), Paula Korhonen(5), Tiina Tikka(4), Tomas Hökfelt(4), Nikolay Naumenko(4), Katja A. Puttonen(4), Pasi Tavi(4), Heikki Tanila(4), Anna–Liisa Levonen(4), Velta Keksa-Goldsteine(4)