Šárka Lehtonen

University of Helsinki — Finland

Neuroscience · Life Sciences

32h-index3.3kcitations114works5.12yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(35), Alzheimer's disease research and treatments(21), Parkinson's Disease Mechanisms and Treatments(15), Pluripotent Stem Cells Research(13), Neurogenesis and neuroplasticity mechanisms(13)

Publications114 total

APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs
Fluids and Barriers of the CNS·2025Open Access
A schizophrenia-associated radial glia cell state perturbs early human brain development
2025Open Access
W66. NEUROBIOLOGICAL CORRELATES OF MALE SEXUAL ORIENTATION
European Neuropsychopharmacology·2025Open Access
APPswe mutation causes functional deficits in endothelial cells generated by transient ETV2 overexpression in human iPSCs
2025Open Access
Human microglia reduce alpha-synuclein aggregation and are neuroprotective in adult mouse brain
Brain Behavior and Immunity·2025Open Access
From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial cells
Fluids and Barriers of the CNS·2025Open Access
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
Journal of Neuroinflammation·2025· 8 citedOpen Access
Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia
Environment International·2025· 5 citedOpen Access
Kynurenic Acid and Promotion of Activity-Dependent Synapse Elimination in Schizophrenia
American Journal of Psychiatry·2025· 5 cited
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype
2025Open Access
miRNA profiling of hiPSC-derived neurons from monozygotic twins discordant for schizophrenia
Schizophrenia·2025Open Access
Optimizing Feature Selection for Unbalanced Metabolomics Data with A Background Factor: A Comparative Study in Parkinson’s Disease
2024Open Access
LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses
International Journal of Molecular Sciences·2024· 2 citedOpen Access
Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells
Fluids and Barriers of the CNS·2024· 4 citedOpen Access
Human iPSC-derived pericyte-like cells carrying the LRRK2 mutation induce a reactive phenotype and alter migration
2024Open Access
The link between amyloid β and ferroptosis pathway in Alzheimer’s disease progression
Cell Death and Disease·2024· 32 citedOpen Access
Uptake of alpha‐synuclein preformed fibrils is suppressed by inflammation and induces an aberrant phenotype in human microglia
Glia·2024· 6 citedOpen Access
LRRK2 G2019S Mutation Affects Human iPSC-Derived Endothelial Cells
Preprints.org·2024Open Access
INDUCED PLURIPOTENT STEM CELL-DERIVED MICROGLIA TO STUDY NLRP3 INFLAMMASOME ACTIVATION IN ALZHEIMER’S DISEASE
Journal of Istanbul Faculty of Medicine / İstanbul Tıp Fakültesi Dergisi·2024Open Access
Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes
Fluids and Barriers of the CNS·2024· 4 citedOpen Access
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Frequent Co-authors

Jari Koıstınaho(42), Tarja Malm(14), Minna Oksanen(12), Marja Koskuvi(12), Katja A. Puttonen(11), Katja M. Kanninen(11), Gundars Goldsteins(11), Sara Wojciechowski(9), Paula Korhonen(9), Anastasia Shakirzyanova(7), Jari Tiihonen(7), Riikka H. Hämäläinen(6), Tuuli-Maria Sonninen(6), Yuriy Pomeshchik(6), Ekaterina Savchenko(6), Hiramani Dhungana(6), Ida Hyötyläinen(6), Ilkka Ojansuu(6), Olli Vaurio(6), Markku Lähteenvuo(6)