Riikka H. Hämäläinen

University of Eastern Finland — Finland

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index5.9kcitations381works4.02yr avg
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Research Topics

Metabolism and Genetic Disorders(30), Mitochondrial Function and Pathology(28), Glycogen Storage Diseases and Myoclonus(14), Genetic Neurodegenerative Diseases(13), Pluripotent Stem Cells Research(11)

Publications63 total

Heightened sensitivity to adverse effects of metformin in mtDNA mutant patient cells
Life Sciences·2025Open Access
LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses
International Journal of Molecular Sciences·2024· 2 citedOpen Access
LRRK2 G2019S Mutation Affects Human iPSC-Derived Endothelial Cells
Preprints.org·2024Open Access
The Roles of Cystatin B in the Brain and Pathophysiological Mechanisms of Progressive Myoclonic Epilepsy Type 1
Cells·2024· 14 citedOpen Access
Generation of a human induced pluripotent stem cell line (UEFi004-A) from a patient with progressive myoclonic epilepsy type 1 (EPM1)
Stem Cell Research·2023· 2 citedOpen Access
The Mitochondrial m.3243A>G Mutation on the Dish, Lessons from In Vitro Models
International Journal of Molecular Sciences·2023· 13 citedOpen Access
Modulating Mitochondrial DNA Heteroplasmy with Mitochondrially Targeted Endonucleases
Annals of Biomedical Engineering·2022· 8 citedOpen Access
Varied Responses to a High m.3243A>G Mutation Load and Respiratory Chain Dysfunction in Patient-Derived Cardiomyocytes
Cells·2022· 18 citedOpen Access
The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception
Scientific Reports·2022· 17 citedOpen Access
Neuron-astrocyte transmitophagy is altered in Alzheimer's disease
Neurobiology of Disease·2022· 85 citedOpen Access
Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model
International Journal of Molecular Sciences·2022· 21 citedOpen Access
Alzheimer’s disease alters astrocytic functions related to neuronal support and transcellular internalization of mitochondria
2021· 1 citedOpen Access
Contributors
Elsevier eBooks·2020
Metabolic alterations in Parkinson’s disease astrocytes
Scientific Reports·2020· 167 citedOpen Access
Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer’s disease
Stem Cell Research·2020· 6 citedOpen Access
Author Correction: Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias
Nature Metabolism·2020· 1 citedOpen Access
Reply to: Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos
Nature Metabolism·2020· 2 citedOpen Access
iPSCs for modeling mtDNA diseases
Elsevier eBooks·2020· 1 cited
NF‐E2‐related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin‐1 mutated Alzheimer's disease astrocytes
Glia·2019· 47 citedOpen Access
Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias
Nature Metabolism·2019· 81 cited
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Frequent Co-authors

Anu Suomalainen(13), Jari Koıstınaho(11), Anna‐Elina Lehesjoki(9), Šárka Lehtonen(8), Minna Oksanen(7), Kati J. Ahlqvist(7), Sanna Ryytty(6), Rashid Giniatullin(5), Tarja Joensuu(5), Jukka Kallijärvi(5), Timo Otonkoski(4), Katja A. Puttonen(4), Tuuli-Maria Sonninen(4), Marja Koskuvi(4), Nikita Mikhailov(4), Marita Lipsanen‐Nyman(4), András Nagy(3), Nikolay Naumenko(3), Anastasia Shakirzyanova(3), Pasi Tavi(3)