Say Kong Ng

Bioprocessing Technology Institute — Singapore

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.7kcitations58works4.12yr avg
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Research Topics

Viral Infectious Diseases and Gene Expression in Insects(38), Protein purification and stability(22), Monoclonal and Polyclonal Antibodies Research(13), Virus-based gene therapy research(11), CRISPR and Genetic Engineering(5)

Publications58 total

Scaled up fed-batch production of recombinant alpha-1-antitrypsin by CHO cells in single-use surface aerated orbital shaken bioreactor
Scientific Reports·2026Open Access
Maltose metabolism in serum free CHO culture involves lysosomal acid α-glucosidase
Scientific Reports·2025Open Access
Functional expression and secretion of basic fibroblast growth factor in Lactococcus lactis
Frontiers in Bioengineering and Biotechnology·2025· 1 citedOpen Access
Streamlined purification of recombinant Alpha-1 antitrypsin from CHO cell culture using integrated chromatography within a single unit operation
Journal of Chromatography A·2025
Affinity resin selection for efficient capture of bispecific antibodies as guided by domain composition
Process Biochemistry·2025· 3 cited
Valorisation of spent cultivated meat media for recombinant FGF2 production in Lactococcus lactis
Systems Microbiology and Biomanufacturing·2025· 3 cited
A risk-based approach can guide safe cell line development and cell banking for scaled-up cultivated meat production
Nature Food·2025· 11 citedOpen Access
Quality by Design in continuous bioprocessing: Investigating the impact of critical process parameters of multi-column chromatography during steady-state and transient phases
Journal of Chromatography A·2024· 3 cited
Exploring cost reduction strategies for serum free media development
npj Science of Food·2024· 19 citedOpen Access
Hybrid modeling for in silico optimization of a dynamic perfusion cell culture process
Biotechnology Progress·2024· 4 citedOpen Access
Investigation on environmental factors contributing to bispecific antibody stability and the reversal of self-associated aggregates
Bioresources and Bioprocessing·2024· 7 citedOpen Access
Valorisation of spent cultivated meat media for recombinant FGF2 production in GRAS <i>Lactococcus lactis</i>
2024· 2 citedOpen Access
Correction: Characterization of a Polyethylene Glycol-Amphotericin B Conjugate Loaded with Free AMB for Improved Antifungal Efficacy
PLoS ONE·2024Open Access
Biomass specific perfusion rate as a control lever for the continuous manufacturing of biosimilar monoclonal antibodies from CHO cell cultures
Biotechnology Journal·2024· 4 citedOpen Access
Temporal insights into molecular and cellular responses during rAAV production in HEK293T cells
Molecular Therapy — Methods & Clinical Development·2024· 4 citedOpen Access
Antibody glycan quality predicted from CHO cell culture media markers and machine learning
Computational and Structural Biotechnology Journal·2024· 5 citedOpen Access
Temporal Insights into Molecular and Cellular Responses during rAAV Production in HEK293T Cells
2023Open Access
Review for "Understanding the effect of temperature downshift on &lt;scp&gt;CHO&lt;/scp&gt; cell growth, antibody titer and product quality by intracellular metabolite profiling and in vivo monitoring of redox state"
2023
Review for "Understanding the effect of temperature downshift on &lt;scp&gt;CHO&lt;/scp&gt; cell growth, antibody titer and product quality by intracellular metabolite profiling and in vivo monitoring of redox state"
2023
Systematic evaluation of genome-wide metabolic landscapes in lactic acid bacteria reveals diet- and strain-specific probiotic idiosyncrasies
Cell Reports·2022· 27 citedOpen Access
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Frequent Co-authors

Meiyappan Lakshmanan(11), Yuansheng Yang(10), Ying Swan Ho(10), Dong‐Yup Lee(10), Xuezhi Bi(8), Hsueh Lee Lim(7), Andy Hee‐Meng Tan(7), Yee Jiun Kok(7), Tessa Rui Min Tan(6), Miranda G.S. Yap(6), Wen Qin Tang(6), Alison Lee(6), Dawn Leong(6), Ian Walsh(5), Peiqing Zhang(5), Shuwen Chen(4), Gavin Teo(4), Christine Lin Chin(4), Terry Nguyen‐Khuong(4), Shi Ya Mak(4)