Miranda G.S. Yap

Agency for Science, Technology and Research — Singapore

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index4.3kcitations79works0.02yr avg
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Research Topics

Viral Infectious Diseases and Gene Expression in Insects(58), Virus-based gene therapy research(22), Protein purification and stability(17), Monoclonal and Polyclonal Antibodies Research(15), Glycosylation and Glycoproteins Research(11)

Publications79 total

Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line
Cell Systems·2017· 107 citedOpen Access
Heat shock protein 27 overexpression in CHO cells modulates apoptosis pathways and delays activation of caspases to improve recombinant monoclonal antibody titre in fed‐batch bioreactors
Biotechnology Journal·2015· 31 cited
Understanding translational control mechanisms of the mTOR pathway in CHO cells by polysome profiling
New Biotechnology·2013· 17 cited
Translatome analysis of CHO cells to identify key growth genes
Journal of Biotechnology·2013· 29 cited
Identification of Autocrine Growth Factors Secreted by CHO Cells for Applications in Single-Cell Cloning Media
Journal of Proteome Research·2013· 49 cited
Adaptations of monoclonal antibody-producing CHO cell lines: Perspectives from genomics, transcriptome, glycomics and metabolomics
HAL (Le Centre pour la Communication Scientifique Directe)·2012
IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines
Journal of Biotechnology·2011· 147 cited
Post-transcriptional Regulatory Elements for Enhancing Transient Gene Expression Levels in Mammalian Cells
Methods in molecular biology·2011· 10 cited
Implications of Vector Fragmentation and Initial Production Levels in Production Cell Line Development Using MTX
2011
Simulation and Optimization of Essential Amino Acids in Dynamic Mammalian Cell Culture
2011
Conserved MicroRNAs in Chinese hamster ovary cell lines
Biotechnology and Bioengineering·2010· 50 cited
Simultaneous Targeting of Requiem & Alg-2 in Chinese Hamster Ovary Cells for Improved Recombinant Protein Production
Molecular Biotechnology·2010· 3 cited
Profiling of <i>N</i>‐glycosylation gene expression in CHO cell fed‐batch cultures
Biotechnology and Bioengineering·2010· 51 cited
An investigation of intracellular glycosylation activities in CHO cells: Effects of nucleotide sugar precursor feeding
Biotechnology and Bioengineering·2010· 137 cited
FGF‐2 modulates Wnt signaling in undifferentiated hESC and iPS cells through activated PI3‐K/GSK3β signaling
Journal of Cellular Physiology·2010· 122 cited
DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines
Journal of Biotechnology·2010· 130 cited
Evaluating regulatory elements of human cytomegalovirus major immediate early gene for enhancing transgene expression levels in CHO K1 and HEK293 cells
Journal of Biotechnology·2010· 21 cited
Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: Overexpression of malate dehydrogenase II
Journal of Biotechnology·2010· 95 cited
Engineering mammalian cells in bioprocessing – current achievements and future perspectives
Biotechnology and Applied Biochemistry·2010· 133 cited
Multitagging Proteomic Strategy to Estimate Protein Turnover Rates in Dynamic Systems
Journal of Proteome Research·2010· 74 cited
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Frequent Co-authors

Kathy Wong(8), Niki S.C. Wong(8), Yih Yean Lee(8), Danny Wong(7), Peter Morin Nissom(7), Daniel I. C. Wang(6), Chew‐Kiat Heng(5), Yuansheng Yang(5), Dong‐Yup Lee(5), Mariati(4), Robin Philp(4), Wei‐Shou Hu(4), Say Kong Ng(4), Wei‐Shou Hu(4), Stephen R. Fox(3), Muriel Bardor(3), Florence Chua(3), Sebastian C. Y. Ku(3), Sheng‐Hao Chao(3), Faraaz N.K. Yusufi(3)