Felix González-López de Turiso

Bristol-Myers Squibb (United States) — United States

Chemistry · Physical Sciences

18h-index1.2kcitations35works7.52yr avg
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Research Topics

Synthetic Organic Chemistry Methods(6), PI3K/AKT/mTOR signaling in cancer(5), Click Chemistry and Applications(5), Synthesis and biological activity(4), Radical Photochemical Reactions(4)

Publications35 total

The next frontier in drug discovery: Unveiling the pharmacological potential of proximity inducers
Elsevier eBooks·2025
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis
Journal of Medicinal Chemistry·2024· 15 citedOpen Access
Selective TYK2 inhibitors as potential therapeutic agents: a patent review (2019–2021)
Expert Opinion on Therapeutic Patents·2022· 23 cited
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation <i>In Vivo</i>
Journal of Medicinal Chemistry·2021· 14 citedOpen Access
Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo
Journal of Medicinal Chemistry·2021· 32 citedOpen Access
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors
ACS Medicinal Chemistry Letters·2020· 22 citedOpen Access
Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors
Journal of Medicinal Chemistry·2019· 34 citedOpen Access
Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1<i>S</i>)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-<i>N</i>-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1<i>S</i>)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-<i>N</i>-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430)
Journal of Medicinal Chemistry·2016· 19 cited
Discovery and in Vivo Evaluation of (<i>S</i>)-<i>N</i>-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9<i>H</i>-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease
Journal of Medicinal Chemistry·2014· 84 cited
Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development
Journal of Medicinal Chemistry·2014· 290 citedOpen Access
Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors
Journal of Medicinal Chemistry·2013· 83 citedOpen Access
Co-crystal structure of MDM2 with inhibitor (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
2013
Co-crystal structure of MDM2 with inhibitor (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
2013
Co-crystal structure of MDM2 with inhibitor (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one
2013
Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors
Journal of Medicinal Chemistry·2012· 2 cited
Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors
Journal of Medicinal Chemistry·2012· 49 citedOpen Access
Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
Journal of Medicinal Chemistry·2012· 166 citedOpen Access
Discovery of AMG 853, a CRTH2 and DP Dual Antagonist
ACS Medicinal Chemistry Letters·2011· 33 citedOpen Access
Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11β-HSD1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 18 citedOpen Access
ChemInform Abstract: Synthesis of Spirocyclopentene‐Indolines by Intramolecular Alkylidine Insertion Reactions.
ChemInform·2008
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Frequent Co-authors

Julio C. Medina(8), Gerald Pattenden(8), Michael D. Bartberger(6), Jonathan D. Oliner(6), Daqing Sun(5), Yosup Rew(5), Lawrence R. McGee(5), P.L. Shaffer(5), Xuelei Yan(5), Qiuping Ye(5), Dennis P. Curran(5), Anna Bertram(5), Jeffrey S. Hannam(5), Katrina A. Jolliffe(5), Martin Himmelbauer(5), J. Howard Jones(5), Paramasivam Murugan(5), Rab Gilfillan(5), Timothy D. Cushing(4), Youngsook Shin(4)