Alyssa J. Lawler

Broad Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index2.1kcitations39works17.32yr avg
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Research Topics

Genomics and Phylogenetic Studies(13), Genomics and Chromatin Dynamics(11), Chromosomal and Genetic Variations(7), Single-cell and spatial transcriptomics(5), Genetic diversity and population structure(4)

Publications35 total

Challenges in Predicting Chromatin Accessibility Differences between Species
2025Open Access
An in vivo systemic massively parallel platform for deciphering animal tissue-specific regulatory function
Frontiers in Genetics·2025· 9 citedOpen Access
Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements
Science·2024· 30 citedOpen Access
Using evolutionary constraint to define novel candidate driver genes in medulloblastoma
Proceedings of the National Academy of Sciences·2023· 4 citedOpen Access
Three-dimensional genome rewiring in loci with human accelerated regions
Science·2023· 102 citedOpen Access
A genomic timescale for placental mammal evolution
Science·2023· 141 citedOpen Access
Evolutionary constraint and innovation across hundreds of placental mammals
Science·2023· 243 citedOpen Access
Mammalian evolution of human cis-regulatory elements and transcription factor binding sites
Science·2023· 107 cited
Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs
Science·2023· 13 citedOpen Access
Relating enhancer genetic variation across mammals to complex phenotypes using machine learning
Science·2023· 80 citedOpen Access
The contribution of historical processes to contemporary extinction risk in placental mammals
Science·2023· 95 citedOpen Access
The functional and evolutionary impacts of human-specific deletions in conserved elements
Science·2023· 71 citedOpen Access
Leveraging base-pair mammalian constraint to understand genetic variation and human disease
Science·2023· 112 citedOpen Access
Integrating gene annotation with orthology inference at scale
Science·2023· 180 citedOpen Access
Insights into mammalian TE diversity through the curation of 248 genome assemblies
Science·2023· 122 citedOpen Access
Chiropterans Are a Hotspot for Horizontal Transfer of DNA Transposons in Mammalia
Molecular Biology and Evolution·2023· 15 citedOpen Access
Leveraging Base Pair Mammalian Constraint to Understand Genetic Variation and Human Disease
2023· 21 citedOpen Access
Evolutionary constraint and innovation across hundreds of placental mammals
2023· 24 citedOpen Access
Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements
2022· 8 citedOpen Access
An <i>in vivo</i> massively parallel platform for deciphering tissue-specific regulatory function
2022· 3 citedOpen Access
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Frequent Co-authors

Irene M. Kaplow(31), Kerstin Lindblad‐Toh(29), Elinor K. Karlsson(29), BaDoi N. Phan(27), Andreas R. Pfenning(23), Diane P. Genereux(22), Wynn K. Meyer(21), Michael X. Dong(20), Gregory Andrews(20), Matthew J. Christmas(19), Matteo Bianchi(19), Kathleen C. Keough(19), Joana Damas(19), Jenna Grimshaw(19), Daniel E. Schäffer(19), Graham M. Hughes(18), Nicole M. Foley(18), Jennifer R. S. Meadows(18), Kaili Fan(18), John Gatesy(18)