Kathleen C. Keough

Personalis (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index5.0kcitations57works8.32yr avg
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Research Topics

Genomics and Phylogenetic Studies(14), Genomics and Chromatin Dynamics(12), Cancer Genomics and Diagnostics(7), Chromosomal and Genetic Variations(6), Genetic diversity and population structure(4)

Publications52 total

Abstract PS2-10-23: Circulating Tumor DNA Dynamics in Patients with Hormone Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer Assessed Using an Ultrasensitive Tumor-Informed Assay
Clinical Cancer Research·2026
Ultrasensitive ctDNA monitoring reveals early predictors of immunotherapy response in advanced cancer
npj Precision Oncology·2026Open Access
Broad Utility of Ultrasensitive Analysis of ctDNA Dynamics across Solid Tumors Treated with Immunotherapy
Clinical Cancer Research·2025· 1 citedOpen Access
Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction
Cell·2025· 3 citedOpen Access
Ultrasensitive circulating tumor DNA (ctDNA) detection for prognostication in triple-negative breast cancer (TNBC) post-neoadjuvant chemotherapy (NAC).
Journal of Clinical Oncology·2025· 1 citedOpen Access
Comparative characterization of human accelerated regions in neurons
Nature·2025· 15 cited
Whole genome sequencing-powered ctDNA sequencing for breast cancer detection
Annals of Oncology·2025· 30 citedOpen Access
Reversal of <i>C9orf72</i> mutation‐induced transcriptional dysregulation and pathology in cultured human neurons by allele‐specific excision
Alzheimer s & Dementia·2024Open Access
223P Tumor whole genome sequencing-based ultrasensitive ctDNA analysis as an early biomarker for clinical outcome in immune checkpoint inhibitor (ICI) phase I clinical trials (Ph1) and a tool for beyond progressive disease by iRECIST
Annals of Oncology·2024· 1 citedOpen Access
Reversal of <i>C9orf72</i> mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision
Proceedings of the National Academy of Sciences·2024· 10 citedOpen Access
Vocal learning–associated convergent evolution in mammalian proteins and regulatory elements
Science·2024· 30 citedOpen Access
Using evolutionary constraint to define novel candidate driver genes in medulloblastoma
Proceedings of the National Academy of Sciences·2023· 4 citedOpen Access
Translational application of adaptive physiology in non-traditional animal models
Physiology·2023
Three-dimensional genome rewiring in loci with human accelerated regions
Science·2023· 102 citedOpen Access
A genomic timescale for placental mammal evolution
Science·2023· 141 citedOpen Access
Evolutionary constraint and innovation across hundreds of placental mammals
Science·2023· 243 citedOpen Access
Mammalian evolution of human cis-regulatory elements and transcription factor binding sites
Science·2023· 107 cited
Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs
Science·2023· 13 citedOpen Access
Relating enhancer genetic variation across mammals to complex phenotypes using machine learning
Science·2023· 80 citedOpen Access
The contribution of historical processes to contemporary extinction risk in placental mammals
Science·2023· 95 citedOpen Access
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Frequent Co-authors

Katherine S. Pollard(33), Kerstin Lindblad‐Toh(32), Elinor K. Karlsson(32), Diane P. Genereux(24), Joana Damas(21), Graham M. Hughes(20), Michael Hiller(20), Harris A. Lewin(20), Michael X. Dong(20), Gregory Andrews(20), Alyssa J. Lawler(20), Klaus‐Peter Koepfli(19), Martin Nweeia(19), Matthew J. Christmas(19), Matteo Bianchi(19), Jenna Grimshaw(19), BaDoi N. Phan(19), Wynn K. Meyer(19), Irene M. Kaplow(18), Nicole M. Foley(18)