Janusz J. Kulagowski

Harlow College — United Kingdom

Chemistry · Physical Sciences

34h-index3.5kcitations95works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Cyclopropane Reaction Mechanisms(15), Neuroscience and Neuropharmacology Research(14), Receptor Mechanisms and Signaling(14), Neurotransmitter Receptor Influence on Behavior(12), Chemical Synthesis and Analysis(10)

Publications95 total

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors
The Journal of Immunology·2013· 123 citedOpen Access
Identification of <i>C</i>-2 Hydroxyethyl Imidazopyrrolopyridines as Potent JAK1 Inhibitors with Favorable Physicochemical Properties and High Selectivity over JAK2
Journal of Medicinal Chemistry·2013· 61 citedOpen Access
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1
Bioorganic & Medicinal Chemistry Letters·2013· 19 citedOpen Access
Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors
Journal of Medicinal Chemistry·2012· 89 citedOpen Access
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
Bioorganic & Medicinal Chemistry Letters·2012· 24 citedOpen Access
Discovery and Optimization of <i>C</i>-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2
Journal of Medicinal Chemistry·2012· 61 citedOpen Access
Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors
Journal of Medicinal Chemistry·2012· 91 citedOpen Access
1‐Phenyl‐8‐azabicyclo[3.2.1]octane Ethers: A Novel Series of Neurokinin (NK<sub>1</sub>) Antagonists.
ChemInform·2006
Synthesis and Structure—Activity Relationships of 8‐Azabicyclo[3.2.1]octane Benzylamine NK<sub>1</sub> Antagonists.
ChemInform·2006
8-Azabicyclo[3.2.1]oct-3-en-2-ones via asymmetric 1,3-dipolar cycloaddition of a homochiral 3-oxidopyridinium betaine
Tetrahedron Letters·2006· 22 cited
1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK1) antagonists
Bioorganic & Medicinal Chemistry Letters·2006· 26 citedOpen Access
Stereoselective Synthesis of a Potent Human NK<sub>1</sub>Receptor Antagonist via Acyl-Claisen Rearrangement
Synlett·2006· 6 cited
Synthesis of (±)-1-Phenyl-2-azabicyclo[2.2.1]heptane Derivatives - Novel NK<sub>1</sub>Receptor Ligands
Synlett·2006· 9 cited
Aminoalkyl phenyl sulfones—a novel series of 5-HT7 receptor ligands
Bioorganic & Medicinal Chemistry Letters·2005· 23 citedOpen Access
Synthesis and structure–activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists
Bioorganic & Medicinal Chemistry Letters·2005· 16 citedOpen Access
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression
Neuropharmacology·2005· 227 cited
Thiazoles and Thiopyridines: Novel Series of High Affinity h5HT<sub>7</sub> Ligands.
ChemInform·2004
Thiazoles and thiopyridines: novel series of high affinity h5HT7 ligands
Bioorganic & Medicinal Chemistry Letters·2003· 31 citedOpen Access
Novel N<sup>1</sup>‐(Benzyl)cinnamamidine Derived NR2B Subtype‐Selective NMDA Receptor Antagonists.
ChemInform·2003
The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor
Neuropharmacology·2003· 99 cited
page 1 of 5Next →

Frequent Co-authors

Paul D. Leeson(14), Neil R. Curtis(12), Linda J. Bristow(10), Ian M. Mawer(9), Raymond Baker(8), Anne van Abbema(7), Christopher A. Hurley(7), Wade Blair(7), Shil Patel(6), Smita S. Patel(6), Peter H. Hutson(6), Pawan Bir Kohli(6), Adam R. Johnson(6), Nico Ghilardi(6), Mark Zak(6), Paul Gibbons(6), Jane R. Kenny(6), Christopher J. Moody(6), Mark P. Ridgill(5), Frances Emms(5)