Paul D. Leeson

John Radcliffe Hospital — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index14.2kcitations152works4.32yr avg
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Research Topics

Chemical Synthesis and Analysis(33), Neuroscience and Neuropharmacology Research(28), Computational Drug Discovery Methods(28), Receptor Mechanisms and Signaling(18), Pharmacogenetics and Drug Metabolism(15)

Publications152 total

Correction to “Pseudonatural Products for Chemical Biology and Drug Discovery”
Journal of Medicinal Chemistry·2025Open Access
Chronotropic incompetency during stress echocardiography: a new paradigm for mortality and cardiac event prediction?
European Journal of Preventive Cardiology·2025Open Access
Prognostic relevance of a false-positive stress echocardiography response: a systematic review and meta-analysis
Open Heart·2025Open Access
Pseudonatural Products for Chemical Biology and Drug Discovery
Journal of Medicinal Chemistry·2025· 12 citedOpen Access
A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds
Scientific Data·2024· 7 citedOpen Access
Occurrence of “Natural Selection” in Successful Small Molecule Drug Discovery
Journal of Medicinal Chemistry·2024· 15 citedOpen Access
Occurrence of ‘Natural Selection’ in Successful Small Molecule Drug Discovery
2024· 2 citedOpen Access
A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds
2024· 3 citedOpen Access
A dataset of compound-target pairs to analyse differences between drugs, clinical candidates and other bioactive compounds
2024Open Access
Physicochemical Properties
2023· 8 citedOpen Access
The Time and Place for Nature in Drug Discovery
JACS Au·2022· 92 citedOpen Access
Target-Based Evaluation of “Drug-Like” Properties and Ligand Efficiencies
Journal of Medicinal Chemistry·2021· 124 citedOpen Access
Setting Our Sights on Infectious Diseases
DSpace@MIT (Massachusetts Institute of Technology)·2019Open Access
Setting Our Sights on Infectious Diseases
ACS Infectious Diseases·2019· 22 citedOpen Access
Impact of Physicochemical Properties on Dose and Hepatotoxicity of Oral Drugs
Chemical Research in Toxicology·2018· 54 cited
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations
Journal of Medicinal Chemistry·2018· 104 citedOpen Access
System and lead extractions
Oxford University Press eBooks·2018
Quality guidelines for oral drug candidates: dose, solubility and lipophilicity
Drug Discovery Today·2016· 117 cited
Molecular inflation, attrition and the rule of five
Advanced Drug Delivery Reviews·2016· 178 cited
An analysis of the attrition of drug candidates from four major pharmaceutical companies
Nature Reviews Drug Discovery·2015· 1.3k cited
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Frequent Co-authors

Robert W. Carling(10), John A. Kemp(8), Alan C. Foster(8), A. M. Davis(6), Janusz J. Kulagowski(6), C I Ragan(6), Kevin W. Moore(6), Neil R. Curtis(5), Raymond Baker(5), Frances Emms(5), Shil Patel(5), George Marshall(5), Stephen B. Freedman(4), Smita S. Patel(4), Angela M. Moseley(4), R. BAKER(4), Sarah Grimwood(4), Kay L. Saywell(4), Mark D. Tricklebank(4), Simon J. Teague(3)