Sarah Grimwood

Pfizer (United States) — United States

Neuroscience · Life Sciences

34h-index2.7kcitations72works14.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Neuroscience and Neuropharmacology Research(39), Receptor Mechanisms and Signaling(34), Neurotransmitter Receptor Influence on Behavior(12), Pharmacological Receptor Mechanisms and Effects(10), Ion channel regulation and function(9)

Publications72 total

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M<sub>4</sub> Muscarinic Acetylcholine Receptor
Journal of Medicinal Chemistry·2024· 14 citedOpen Access
Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres
ACS Medicinal Chemistry Letters·2019· 14 citedOpen Access
Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors
ACS Chemical Neuroscience·2017· 25 cited
Design and Synthesis of γ- and δ-Lactam M<sub>1</sub> Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M<sub>1</sub>-Selective PAM with Weak Agonist Activity
Journal of Medicinal Chemistry·2017· 58 citedOpen Access
Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M<sub>1</sub> Receptor Activation
Biochemistry·2016· 14 cited
Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain
European Journal of Nuclear Medicine and Molecular Imaging·2016· 9 citedOpen Access
Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284
Molecular Pharmacology·2016· 7 cited
Discovery of the Potent and Selective M1 PAM-Agonist<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-Hydroxytetrahydro-2<i>H</i>-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects
Journal of Medicinal Chemistry·2016· 83 citedOpen Access
Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D2 Receptor Occupancy
Pharmaceutical Research·2016· 1 citedOpen Access
Translational Modeling in Schizophrenia: Predicting Human Dopamine D2 Receptor Occupancy
Pharmaceutical Research·2015· 15 citedOpen Access
Design and optimization of selective azaindole amide M1 positive allosteric modulators
Bioorganic & Medicinal Chemistry Letters·2015· 44 citedOpen Access
Meet Our Editorial Board Member
Letters in Drug Design & Discovery·2015
Application of cross-species PET imaging to assess neurotransmitter release in brain
Psychopharmacology·2015· 76 citedOpen Access
Design, synthesis and evaluation of [3H]PF-7191, a highly specific nociceptin opioid peptide (NOP) receptor radiotracer for in vivo receptor occupancy (RO) studies
Bioorganic & Medicinal Chemistry Letters·2014· 15 cited
Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test–retest reproducibility and receptor occupancy by the antagonist PF-04455242
NeuroImage·2014· 56 citedOpen Access
Dopamine D2 Receptor Occupancy as a Predictor of Catalepsy in Rats: A Pharmacokinetic-Pharmacodynamic Modeling Approach
Pharmaceutical Research·2014· 12 cited
Poster #S45 DEVELOPMENT OF NOVEL PET LIGANDS (PF-04831704 AND PF-06327104) FOR PDE10A
Schizophrenia Research·2014· 1 cited
Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1 <i>H</i> -pyrazolo-[3,4- <i>b</i> ]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator
Journal of Medicinal Chemistry·2014· 51 citedOpen Access
Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand
Journal of Medicinal Chemistry·2013· 199 citedOpen Access
[11C]RO6899880, a novel agonist PET radioligand for the GABAA receptor
2013· 2 cited
page 1 of 4Next →

Frequent Co-authors

Paul D. Leeson(8), Lei Zhang(7), Alan C. Foster(7), George Marshall(7), Peter H. Hutson(7), Kay L. Saywell(6), Michael A. Brodney(6), John T. Lazzaro(6), Patrick R. Verhoest(5), John A. Kemp(5), Jeremy R. Edgerton(5), Susan M. Lotarski(5), Michael Popiolek(5), Stefanus J. Steyn(5), Michelle Vanase‐Frawley(5), Fraser Murray(5), Robert W. Carling(4), Michael Rowley(4), Janusz J. Kulagowski(4), Jennifer E. Davoren(4)