Susan M. Lotarski

Pfizer (United States) — United States

Neuroscience · Life Sciences

18h-index964citations30works14.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(13), Receptor Mechanisms and Signaling(10), Ion channel regulation and function(7), Nicotinic Acetylcholine Receptors Study(6), Pharmacological Receptor Mechanisms and Effects(6)

Publications30 total

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M<sub>4</sub> Muscarinic Acetylcholine Receptor
Journal of Medicinal Chemistry·2024· 14 citedOpen Access
<i>In Vivo</i> Modulation of Hippocampal Excitability by M4 Muscarinic Acetylcholine Receptor Activator: Implications for Treatment of Alzheimer’s Disease and Schizophrenic Patients
ACS Chemical Neuroscience·2018· 24 cited
[P3–046]: NOVEL NON‐CATECHOL D1 RECEPTOR AGONISTS EXHIBIT SUSTAINED PHARMACOLOGICAL ACTIVITY
Alzheimer s & Dementia·2017
[P3–044]: FUNCTIONAL AND PHARMACOLOGICAL CHARACTERIZATION OF A NOVEL AND SELECTIVE MUSCARINIC ACETYLCHOLINE M4 RECEPTOR ACTIVATOR
Alzheimer s & Dementia·2017Open Access
Design and Synthesis of γ- and δ-Lactam M<sub>1</sub> Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M<sub>1</sub>-Selective PAM with Weak Agonist Activity
Journal of Medicinal Chemistry·2017· 58 citedOpen Access
Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M<sub>1</sub> Receptor Activation
Biochemistry·2016· 14 cited
Discovery of the Potent and Selective M1 PAM-Agonist<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-Hydroxytetrahydro-2<i>H</i>-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects
Journal of Medicinal Chemistry·2016· 83 citedOpen Access
Design and optimization of selective azaindole amide M1 positive allosteric modulators
Bioorganic & Medicinal Chemistry Letters·2015· 44 citedOpen Access
The Discovery and Characterization of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator <i>N</i> -{(3 <i>S</i> ,4 <i>S</i> )-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)
Journal of Medicinal Chemistry·2015· 29 cited
CCDC 1402068: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
Behavioral characterization of striatal‐enriched protein tyrosine phosphatase (<scp>STEP</scp>) knockout mice
Genes Brain & Behavior·2014· 13 citedOpen Access
Poster #S15 A MOUSE MODEL OF 22Q11 DELETION SYNDROME EXHIBITS DEFICITS IN BEHAVIORS RELEVANT TO THE CORE DOMAINS OF SCHIZOPHRENIA
Schizophrenia Research·2014
Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants
Epilepsy Research·2014· 33 cited
Behavioral Characterization of A53T Mice Reveals Early and Late Stage Deficits Related to Parkinson’s Disease
PLoS ONE·2013· 185 citedOpen Access
Positive Allosteric Modulation of AMPA Receptors from Efficacy to Toxicity: The Interspecies Exposure-Response Continuum of the Novel Potentiator PF-4778574
Journal of Pharmacology and Experimental Therapeutics·2013· 61 cited
Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression
Neuropharmacology·2012· 85 cited
Anxiolytic-Like Activity of Pregabalin in the Vogel Conflict Test in α2δ-1 (R217A) and α2δ-2 (R279A) Mouse Mutants
Journal of Pharmacology and Experimental Therapeutics·2011· 52 cited
Oxadiazolone bioisosteres of pregabalin and gabapentin
Bioorganic & Medicinal Chemistry Letters·2008· 14 cited
Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 23 citedOpen Access
Carboxylate bioisosteres of pregabalin
Bioorganic & Medicinal Chemistry Letters·2006· 16 cited
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Frequent Co-authors

Charles P. Taylor(12), Mark L. Weber(8), Michael Rafferty(8), George P. Miljanich(8), Elizabeth Millerman(8), John T. Lazzaro(7), Mark G. Vartanian(7), David M. Rock(7), Sally J. Stoehr(7), Balázs Szőke(7), Michael Popiolek(6), Jacob B. Schwarz(6), Todd R. Ryder(6), Jeremy R. Edgerton(5), Stefanus J. Steyn(5), Sarah Grimwood(5), Sean D. Donevan(5), Ayman El‐Kattan(5), Jack J. Kinsora(5), Lain‐Yen Hu(5)