Michael Popiolek

Medical University of Warsaw — Poland

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index976citations29works5.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(18), Neuroscience and Neuropharmacology Research(15), Nicotinic Acetylcholine Receptors Study(6), Amino Acid Enzymes and Metabolism(4), Neuropeptides and Animal Physiology(3)

Publications29 total

Quantum mechanics-driven structure-activity relationship study of PEX5-PEX14 protein-protein interaction inhibitors based on a dibenzo[b,e]azepin-6(6H)-one scaffold
European Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Quantum Mechanics-Driven Structure-Activity Relationship Study of Pex5-Pex14 Protein-Protein Interaction Inhibitors Based on a Dibenzo[B,E]Azepin-6(6h)-One Scaffold
SSRN Electronic Journal·2025Open Access
Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M<sub>4</sub> Muscarinic Acetylcholine Receptor
Journal of Medicinal Chemistry·2024· 14 citedOpen Access
Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia
American Journal of Psychiatry·2022· 128 cited
P599. The Muscarinic Agonist Xanomeline Demonstrates Standalone Activity and Augments Clinical Antipsychotics in Rodent Behavioral Models of Psychosis
Biological Psychiatry·2022
P.0837 Xanomeline's activity in rodent models of psychosis: Role of central muscarinic receptors and augmentation by antipsychotic drugs
European Neuropsychopharmacology·2021
Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo
Frontiers in Molecular Neuroscience·2020· 24 citedOpen Access
D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited Dyskinesia Side Effects
ACS Chemical Neuroscience·2020· 26 cited
Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline
ACS Chemical Neuroscience·2019· 9 cited
Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres
ACS Medicinal Chemistry Letters·2019· 14 citedOpen Access
Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline
ACS Chemical Neuroscience·2018· 32 cited
<i>In Vivo</i> Modulation of Hippocampal Excitability by M4 Muscarinic Acetylcholine Receptor Activator: Implications for Treatment of Alzheimer’s Disease and Schizophrenic Patients
ACS Chemical Neuroscience·2018· 24 cited
Meta‐analysis of amantadine efficacy for improving preclinical research reliability
Movement Disorders·2018· 7 cited
Lack of Effect of Sodium Benzoate at Reported Clinical Therapeutic Concentration on <scp>d</scp>-Alanine Metabolism in Dogs
ACS Chemical Neuroscience·2018· 12 cited
Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease
Neuropharmacology·2017· 130 cited
FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system
Molecular Psychiatry·2017· 36 citedOpen Access
[P3–044]: FUNCTIONAL AND PHARMACOLOGICAL CHARACTERIZATION OF A NOVEL AND SELECTIVE MUSCARINIC ACETYLCHOLINE M4 RECEPTOR ACTIVATOR
Alzheimer s & Dementia·2017Open Access
Design and Synthesis of γ- and δ-Lactam M<sub>1</sub> Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M<sub>1</sub>-Selective PAM with Weak Agonist Activity
Journal of Medicinal Chemistry·2017· 58 citedOpen Access
Effects of <scp>M</scp>1 and <scp>M</scp>4 activation on excitatory synaptic transmission in <scp>CA</scp>1
Hippocampus·2017· 52 citedOpen Access
Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M<sub>1</sub> Receptor Activation
Biochemistry·2016· 14 cited
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Frequent Co-authors

Jeremy R. Edgerton(8), Stefanus J. Steyn(7), John T. Lazzaro(6), Susan M. Lotarski(6), Rouba Kozak(6), Nicholas J. Brandon(5), Catherine A. Thorn(5), Sarah Grimwood(5), John F. Harms(4), Eda Stark(4), Rebecca E. O’Connor(4), Christopher R. Butler(4), Mark H. Pausch(3), Karen L. Marquis(3), Samantha E. Yohn(3), Christian C. Felder(3), Jennifer E. Davoren(3), Michael A. Brodney(3), Veronica Reinhart(3), Damien Webb(3)