Jeremy R. Edgerton

Pfizer (United States) — United States

Neuroscience · Life Sciences

19h-index1.6kcitations36works14.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(22), Neurological disorders and treatments(11), Receptor Mechanisms and Signaling(11), Neural dynamics and brain function(10), Neuroscience and Neural Engineering(7)

Publications36 total

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M<sub>4</sub> Muscarinic Acetylcholine Receptor
Journal of Medicinal Chemistry·2024· 14 citedOpen Access
Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline
ACS Chemical Neuroscience·2019· 9 cited
Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline
ACS Chemical Neuroscience·2018· 32 cited
Muscarinic receptor subtype distribution in the central nervous system and relevance to aging and Alzheimer's disease
Neuropharmacology·2017· 130 cited
Design and Synthesis of γ- and δ-Lactam M<sub>1</sub> Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M<sub>1</sub>-Selective PAM with Weak Agonist Activity
Journal of Medicinal Chemistry·2017· 58 citedOpen Access
Effects of <scp>M</scp>1 and <scp>M</scp>4 activation on excitatory synaptic transmission in <scp>CA</scp>1
Hippocampus·2017· 52 citedOpen Access
Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M<sub>1</sub> Receptor Activation
Biochemistry·2016· 14 cited
Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284
Molecular Pharmacology·2016· 7 cited
Discovery of the Potent and Selective M1 PAM-Agonist<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-Hydroxytetrahydro-2<i>H</i>-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects
Journal of Medicinal Chemistry·2016· 83 citedOpen Access
Design and optimization of selective azaindole amide M1 positive allosteric modulators
Bioorganic & Medicinal Chemistry Letters·2015· 44 citedOpen Access
Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mouse reveals classic inhibition with little potential for rebound activation
Frontiers in Cellular Neuroscience·2014· 25 citedOpen Access
Electrophysiological recordings in rats performing the sustained attention task
The FASEB Journal·2013
Future Viable Models of Psychiatry Drug Discovery in Pharma
SLAS DISCOVERY·2013· 14 citedOpen Access
Robustness, variability, phase dependence, and longevity of individual synaptic input effects on spike timing during fluctuating synaptic backgrounds: A modeling study of globus pallidus neuron phase response properties
Neuroscience·2012· 9 citedOpen Access
Dendritic sodium channels promote active decorrelation and reduce phase locking to parkinsonian input oscillations in model globus pallidus neurons
Journal of Neuroscience Nursing·2011
Dendritic Sodium Channels Promote Active Decorrelation and Reduce Phase Locking to Parkinsonian Input Oscillations in Model Globus Pallidus Neurons
Journal of Neuroscience·2011· 25 citedOpen Access
The use of automated parameter searches to improve ion channel kinetics for neural modeling
Journal of Computational Neuroscience·2011· 22 cited
Dendritic Sodium Channels Regulate Network Integration in Globus Pallidus Neurons: A Modeling Study
Journal of Neuroscience·2010· 25 citedOpen Access
The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites
Journal of Computational Neuroscience·2010· 66 citedOpen Access
Phase response analysis during in vivo-like high conductance states; dendritic SK determines the mean and variance of responses to dendritic excitation
BMC Neuroscience·2010· 4 citedOpen Access
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Frequent Co-authors

Dieter Jaeger(17), Michael Popiolek(8), John T. Lazzaro(7), Stefanus J. Steyn(7), Sarah Grimwood(7), Cengiz Günay(6), Nathan W. Schultheiss(6), Catherine A. Thorn(5), Jennifer E. Davoren(5), Susan M. Lotarski(5), Michael A. Brodney(4), Lei Zhang(4), Eric B. Hendrickson(4), Che‐Wah Lee(3), Michelle R. Garnsey(3), Anthony R. Harris(3), Steven V. O’Neil(3), Veronica Reinhart(3), Damien Webb(3), Eda Stark(3)