Steven V. O’Neil

Pfizer (United States) — United States

Chemistry · Physical Sciences

18h-index858citations40works7.32yr avg
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Research Topics

Oxidative Organic Chemistry Reactions(8), Chemical Synthesis and Analysis(6), Asymmetric Synthesis and Catalysis(5), Neuroscience and Neuropharmacology Research(5), Synthesis and biological activity(4)

Publications40 total

Generation of Polysubstituted Tetrahydrofurans via Urea-Enabled, Pd-Catalyzed Olefin Heteroannulation
2025· 1 citedOpen Access
Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease
Journal of Medicinal Chemistry·2025· 15 cited
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants
Nature Communications·2025· 6 citedOpen Access
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life
ACS Medicinal Chemistry Letters·2023· 3 citedOpen Access
Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro[4.5]decan-3-amine
Organic Process Research & Development·2021· 17 cited
Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity
Journal of Medicinal Chemistry·2019· 33 cited
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
Journal of Medicinal Chemistry·2018· 78 citedOpen Access
Discovery and Characterization of (<i>R</i>)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-<i>c</i>][1,4]oxazin-4(9<i>H</i>)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
Journal of Medicinal Chemistry·2017· 9 citedOpen Access
Design and Synthesis of γ- and δ-Lactam M<sub>1</sub> Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M<sub>1</sub>-Selective PAM with Weak Agonist Activity
Journal of Medicinal Chemistry·2017· 58 citedOpen Access
Discovery of the Potent and Selective M1 PAM-Agonist<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-Hydroxytetrahydro-2<i>H</i>-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects
Journal of Medicinal Chemistry·2016· 83 citedOpen Access
Design and optimization of selective azaindole amide M1 positive allosteric modulators
Bioorganic & Medicinal Chemistry Letters·2015· 44 citedOpen Access
Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression
Neuropharmacology·2012· 85 cited
Advances in the development of novel aggrecanase inhibitors
Expert Opinion on Therapeutic Patents·2010· 36 cited
CCDC 608956: Experimental Crystal Structure Determination
The Cambridge Structural Database·2007Open Access
Synthesis and evaluation of unsaturated caprolactams as interleukin-1β converting enzyme (ICE) inhibitors
Bioorganic & Medicinal Chemistry·2006· 18 citedOpen Access
Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors
Bioorganic & Medicinal Chemistry·2006· 14 cited
Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis
Bioorganic & Medicinal Chemistry Letters·2006· 49 citedOpen Access
Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 16 citedOpen Access
Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 41 citedOpen Access
Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1β converting enzyme (ICE) inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 6 citedOpen Access
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Frequent Co-authors

Barry B. Snider(11), Michael C. Laufersweiler(9), Yili Wang(9), Kofi A. Oppong(8), Christopher D. Ellis(8), David L. Soper(8), John A. Wos(8), Amy N. Fancher(8), Maureen K. Suchanek(7), Deane M. Nason(6), Mark W. Baize(6), Richard L. Wang(6), Michelle R. Garnsey(5), Lei Zhang(5), Thomas P. Demuth(5), Biswanath De(5), Wei Lü(5), Susan M. Lotarski(4), Michael A. Brodney(4), Anthony R. Harris(4)